Evidence map›Paper›PMID 27638419›Full record

ArticleGenetics2016

A Variable Genetic Architecture of Melanic Evolution in Drosophila melanogaster.

Héloïse Bastide, Jeremy D Lange, Justin B Lack, Amir Yassin, John E Pool

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  14. Ethanol resistance inEcology and evolution · 2021
    Article
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  18. Evolutionary dynamics of recent selection on cognitive abilities.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Assessing the Architecture ofG3 (Bethesda, Md.) · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Héloïse BastideLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Jeremy D LangeLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Justin B LackLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Amir YassinLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706.
John E PoolLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706 jpool@wisc.edu.ORCID 0000-0003-2968-9545
University of Wisconsin–Madison · US

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Causes and Consequences of Size Evolution in Drosophila melanogasterR01GM111797 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI POOL, JOHN E · 2014 to 2018
$1.4M
NHGRI NIH HHS T32 HG002760NIGMS NIH HHS R01 GM111797NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Unraveling the genetic architecture of adaptive phenotypic divergence is a fundamental quest in evolutionary biology. In Drosophila melanogaster, high-altitude melanism has evolved in separate mountain ranges in sub-Saharan Africa, potentially as an adaptation to UV intensity. We investigated the genetic basis of this melanism in three populations using a new bulk segregant analysis mapping method. We identified 19 distinct QTL regions from nine mapping crosses, with several QTL peaks overlapping between two or all populations, and yet different crosses involving the same melanic population commonly yielded distinct QTL. The strongest QTL often overlapped well-known pigmentation genes, but we typically did not find wide signals of genetic differentiation (F

Indexed as

Evolution, MolecularAnimalsDrosophila melanogasterMelaninsPolymorphism, Single NucleotideQuantitative Trait LociSkin PigmentationMelaninsadaptationbulk segregant analysisDrosophila melanogasterparallel evolutionpigmentationstanding genetic variation

Identifiers

PMID27638419
PMCPMC5105859
OpenAlexW2520938469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.