Evidence map›Paper›PMID 27638339›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2017

Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.

Sirpa Loukovaara, Jouko Sandholm, Kristiina Aalto, Janne Liukkonen, Sirpa Jalkanen, Gennady G Yegutkin

Open access · greenAbstract read
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In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Integration of Adenylate Kinase 1 with Its Peptide Conformational Imprint.International journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Fluorescent Probes for Ecto-5'-nucleotidase (CD73).ACS medicinal chemistry letters · 2020
    Article
  10. Observational
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sirpa LoukovaaraUnit of Vitreoretinal Surgery, Department of Ophthalmology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Jouko SandholmCell Imaging Core, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Kristiina AaltoMediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Janne LiukkonenDepartment of Ophthalmology, Turku University Hospital, Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.
Gennady G YegutkinMediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Tykistökatu 6A, 20520, Turku, Finland. gennady.yegutkin@utu.fi.
University of Turku · FITurku Centre for Biotechnology · FITurku University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear signaling roles for ATP and adenosine have been established in all tissues, including the eye. The magnitude of signaling responses is governed by networks of enzymes; however, little is known about the regulatory mechanisms of purinergic signaling in the eye. By employing thin-layer chromatographic assays with KEY MESSAGE: Ecto-5'-nucleotidase/CD73 and adenylate kinase-1 circulate in human vitreous fluid. Adenylate kinase activity is high in diabetic eyes with proliferative retinopathy. Diabetic eyes display higher intravitreal ATP/ADP ratio than non-diabetic controls. Soluble adenylate kinase maintains resynthesis of inflammatory ATP in diabetic eyes.

Indexed as

5'-NucleotidaseAdenosineAdenosine DiphosphateAdenosine TriphosphateAdenylate KinaseAdultAgedChromatography, Thin LayerDiabetic RetinopathyErythropoietinFemaleHumansMaleMiddle AgedNucleoside-Diphosphate KinaseRetina5'-NucleotidaseAdenosineAdenosine DiphosphateAdenosine TriphosphateAdenylate Kinaseadenylate kinase 1ErythropoietinNucleoside-Diphosphate KinaseVascular Endothelial Growth Factor AVEGFA protein, humanAdenylate kinase-1ADPATPDiabetic retinopathyEcto-5′-nucleotidase/CD73Vitreous fluid

Identifiers

PMID27638339
OpenAlexW2520416457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.