Evidence map›Paper›PMID 27638293›Full record

ArticleAging2016

Protective effects of alpha phenyl-tert-butyl nitrone and ascorbic acid in human adipose derived mesenchymal stem cells from differently aged donors.

Adiv A Johnson, Yahaira Naaldijk, Christian Hohaus, Hans Jörg Meisel, Ilona Krystel, Alexandra Stolzing

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020
    Review
  3. Bestrophin 1 and retinal disease.Progress in retinal and eye research · 2017
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Adiv A JohnsonDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
Yahaira NaaldijkTranslational Centre for Regenerative Medicine (TRM), Leipzig University, Leipzig, Germany.
Christian HohausDepartment of Neurosurgery, BG Clinic Bergmannstrost Halle, Germany.
Hans Jörg MeiselDepartment of Neurosurgery, BG Clinic Bergmannstrost Halle, Germany.
Ilona KrystelFraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
Alexandra StolzingTranslational Centre for Regenerative Medicine (TRM), Leipzig University, Leipzig, Germany.
BG Klinikum Bergmannstrost Halle · DEFraunhofer Institute for Cell Therapy and Immunology · DELeipzig University · DELoughborough University · GBWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) are multipotent stem cells that promote therapeutic effects and are frequently used in autologous applications. Little is known about how ADSCs respond to genotoxic stress and whether or not donor age affects DNA damage and repair. In this study, we used the comet assay to assess DNA damage and repair in human ADSCs derived from young (20-40 years), middle-aged (41-60 years), and older (61+ years) donors following treatment with H

Indexed as

Adipose TissueAdultAgingAscorbic AcidCyclic N-OxidesDNA DamageHumansHydrogen PeroxideMesenchymal Stem CellsMiddle AgedNitrogen OxidesUltraviolet RaysYoung AdultAscorbic AcidCyclic N-OxidesHydrogen PeroxideNitrogen Oxidesnitronesphenyl-N-tert-butylnitroneADSCsagingantioxidantscomet assayDNA damageDNA repair

Identifiers

PMID27638293
PMCPMC5361667
OpenAlexW2520798122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.