ArticlePediatrics international : official journal of the Japan Pediatric Society2017
Household siblings and nasal and fecal microbiota in infants.
Article in Pediatrics international : official journal of the Japan Pediatric Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Comparison of nasal microbiota between preterm and full-term infants in early life.Pediatric research · 2025Article
- Observational
- Interactions with alloparents are associated with the diversity of infant skin and fecal bacterial communities in Chicago, United States.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Birth and household exposures are associated with changes to skin bacterial communities during infancy.Evolution, medicine, and public health · 2025Article
- Does having siblings really protect against childhood atopic diseases? A total population and within-family analysis.European journal of epidemiology · 2024Article
- Exposure to Disinfectants and Cleaning Products and Respiratory Health of Workers and Children in Daycares: The CRESPI Cohort Protocol.International journal of environmental research and public health · 2023Article
- The establishment of the gut microbiota in 1-year-aged infants: from birth to family food.European journal of nutrition · 2022Observational
- Prenatal exposure to Hurricane Maria is associated with an altered infant nasal microbiome.The journal of allergy and clinical immunology. Global · 2022Article
- The developing airway and gut microbiota in early life is influenced by age of older siblings.Microbiome · 2022Article
- Interactions of the bacteriome, virome, and immune system in the nose.FEMS microbes · 2022Review
- Infant Skin Bacterial Communities Vary by Skin Site and Infant Age across Populations in Mexico and the United States.mSystems · 2020Article
- Maternal Fish Consumption in Pregnancy Is Associated with aCurrent developments in nutrition · 2020Article
- Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis.The Journal of allergy and clinical immunology · 2019Article
- Immunity, microbiota and kidney disease.Nature reviews. Nephrology · 2019Review
- Differences in the fecal microbiota of neonates born at home or in the hospital.Scientific reports · 2018Article
- The hygiene hypothesis: immunological mechanisms of airway tolerance.Current opinion in immunology · 2018Review
- Microbial diversity within the airway microbiome in chronic pediatric lung diseases.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.The Journal of allergy and clinical immunology · 2018Article
- Microbiome and asthma.Asthma research and practice · 2018Review
- Association of Maternal Gestational Weight Gain With the Infant Fecal Microbiota.Journal of pediatric gastroenterology and nutrition · 2017Observational
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEarly-life exposure to older siblings is associated with a lower risk of asthma. To date, no study has addressed the impact of having siblings on both the airway and fecal microbiota during infancy. The aim of this study was therefore to profile the nasal airway and fecal microbiota in infants, and to examine the association between having siblings and microbiota profile.
methodsWe conducted a cross-sectional study of 105 healthy infants (aged <1 year). Using 16S rRNA gene sequencing and an unbiased clustering approach to the nasal airway and fecal samples, we identified microbiota profiles and then determined the association between having siblings and microbiome profile.
resultsOverall, the median age was 3.4 months (IQR, 2.0-4.7 months); 43% had siblings in the household. Unbiased clustering of nasal airway microbiota identified three profiles: Moraxella dominant (43%), Corynebacterium/Dolosigranulum dominant (36%), and mixed (21%). Infants with siblings were more likely to have a Moraxella-dominant profile than Corynebacterium/Dolosigranulum-dominant profile (76% vs 18%), while those without siblings had the opposite pattern (18% vs 50%; P < 0.001, multivariable-adjusted). Fecal microbiota consisted of three profiles: Bifidobacterium dominant (39%), Escherichia dominant (31%), and Enterobacter dominant (30%). Infants with siblings were more likely to have a Bifidobacterium-dominant profile than Escherichia-dominant profile (49% vs 24%) while those without siblings had the opposite pattern (32% vs 37%; P = 0.04, multivariable-adjusted).
conclusionsIn this cross-sectional study, infants with siblings were more likely to have a Moraxella-dominant nasal microbiota profile and Bifidobacterium-dominant fecal microbiota profile. These findings should facilitate further investigation of the interplay between early-life environmental exposure, the microbiome, and childhood asthma.
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