Evidence map›Paper›PMID 27637205›Full record

SynthesisWiener klinische Wochenschrift2016

Association between apolipoprotein B EcoRI polymorphisms and coronary heart disease : A meta-analysis.

Yeda Chen, Jingtang Zeng, Yiqing Tan, Min Feng, Jiheng Qin, Meihua Lin, Xiang Zhao, Xiaolei Zhao, Yan Liang, Naizun Zhang and 1 more

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Wiener klinische Wochenschrift, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yeda ChenInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Jingtang ZengInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Yiqing TanInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Min FengInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Jiheng QinInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Meihua LinInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Xiang ZhaoInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Xiaolei ZhaoInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China.
Yan LiangMaoming People's Hospital, Maoming, Guangdong, China.
Naizun ZhangMaoming People's Hospital, Maoming, Guangdong, China.
Shaoqi RaoInstitute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China. raoshaoq@gdmc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study was carried out to examine the association between apolipoprotein B (ApoB) EcoRI polymorphism (E

methodsThe Hardy-Weinberg equilibrium (HWE) test was applied to assess genotype frequency distribution in healthy controls. The quality of the studies was assessed using the Newcastle-Ottawa scale (NOS). Power analysis was performed with Power and Precision V4 software. A fixed effect model was used because no deviation from homogeneity was found. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression method. The meta-analysis was performed by Stata 12.0 software.

resultsA total of 21 eligible association studies were merged in this meta-analysis and the pooled sample consisted of 2994 CHD patients and 3258 healthy controls. No significant publication bias and heterogeneity were observed in these studies. The pooled odds ratio (OR) and 95% confidence interval (CI) of E

conclusionsThis meta-analysis indicated that ApoB EcoRI confers a moderate risk for CHD and the E

Indexed as

Apolipoproteins BCoronary Artery DiseaseFemaleGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotidePrevalenceReproducibility of ResultsRisk AssessmentSensitivity and SpecificityApolipoproteins BGenetic MarkersApolipoprotein BCase-control studyCoronary heart diseaseEcoRI polymorphismsMeta-analysis

Identifiers

PMID27637205

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.