ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Indication for Dialysis Initiation and Mortality in Patients With Chronic Kidney Failure: A Retrospective Cohort Study.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Update of dialysis initiation timing in end stage kidney disease patients: is it a resolved question? A systematic literature review.BMC nephrology · 2023Pooled it
- Methodological Concerns and Interpretive Limitations in "Transvenous Lead Extraction Outcomes in Hemodialysis Patients".Journal of cardiovascular electrophysiology · 2026Article
- Clinical indications for dialysis: a study of patient demographics at Hargeisa Group Hospital, Somaliland.BMC nephrology · 2026Article
- A prescription-based model for predicting post-hemodialysis urea and electrolytes: a real-world validation study in acute hemodialysis.BMC nephrology · 2025Article
- Derivation and Validation of a Machine Learning Model for the Prevention of Unplanned Dialysis.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Loop diuretics improve conditions of dialysis inception in advanced CKD: an observational cohort study.Journal of nephrology · 2023Observational
- Social determinants of health and the transition from advanced chronic kidney disease to kidney failure.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Effect of emergency start and central venous catheter on outcomes in incident hemodialysis patients: a prospective observational cohort.Journal of nephrology · 2022Observational
- Most emergency department patients meeting sepsis criteria are not diagnosed with sepsis at discharge.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Impact on survival of urgent dialysis initiation in patients with end-stage renal disease: a case-control study.Clinical and experimental nephrology · 2020Observational
- Factors associated with quality of life among chronic kidney disease patients in Nepal: a cross-sectional study.Health and quality of life outcomes · 2020Article
- In-hospital mortality among incident hemodialysis older patients in Peru.International health · 2020Article
- An Equation Based on Fuzzy Mathematics to Assess the Timing of Haemodialysis Initiation.Scientific reports · 2019Article
- Association between timing of peritoneal dialysis initiation and mortality in end-stage renal disease.Chronic diseases and translational medicine · 2019Article
- Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Article
- Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study.BMC nephrology · 2018Article
- Improving the prognosis of patients with severely decreased glomerular filtration rate (CKD G4+): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2018Article
- Disparities in early mortality among chronic kidney disease patients who transition to peritoneal dialysis and hemodialysis with and without catheters.International urology and nephrology · 2018Article
- Timing of Dialysis Initiation: What Has Changed Since IDEAL?Seminars in nephrology · 2017Review
- The Transition From the Pre-ESRD to ESRD Phase of CKD: Much Remains to Be Learned.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInitiation of maintenance dialysis therapy for patients with chronic kidney failure is a period of high risk for adverse patient outcomes. Whether indications for dialysis therapy initiation are associated with mortality in this population is unknown. STUDY
designRetrospective cohort study. SETTING &
participants461 patients who initiated dialysis therapy (hemodialysis, 437; peritoneal dialysis, 24) from January 1, 2004, through December 31, 2012, and were treated in facilities operated by a single dialysis organization. Follow-up for the primary outcome was through December 31, 2013. PREDICTOR: Clinically documented primary indication for dialysis therapy initiation, as categorized into 4 groups: laboratory evidence of kidney function decline (reference category), uremic symptoms, volume overload or hypertension, and other/unknown. OUTCOMES: All-cause mortality.
resultsDuring a median follow-up of 2.4 years, 183 (40%) patients died. Crude mortality rates were 10.0 (95% CI, 6.8-14.7), 12.7 (95% CI, 10.2-15.7), 21.7 (95% CI, 16.4-28.6), and 12.2 (95% CI, 6.8-14.7) deaths/100 patient-years among patients initiating dialysis therapy primarily for laboratory evidence of kidney function decline, uremic symptoms, volume overload or hypertension, and other/unknown reason, respectively. Following adjustment for demographic variables, coexisting illnesses, and estimated glomerular filtration rate, initiation of dialysis therapy for uremic symptoms, volume overload or hypertension, or other/unknown reasons was associated with 1.12 (95% CI, 0.72-1.77), 1.69 (95% CI, 1.02-2.80), and 1.28 (95% CI, 0.73-2.26) times higher risk, respectively, for subsequent mortality compared to initiation for laboratory evidence of kidney function decline. LIMITATIONS: Possibility of residual confounding by unmeasured variables; reliance on clinical documentation to ascertain exposure.
conclusionsPatients initiating dialysis therapy due to volume overload may have increased risk for mortality compared with patients initiating dialysis due to laboratory evidence of kidney function decline. Further studies are needed to identify and test interventions that might reduce this risk.
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