ArticleOncotarget2016
A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Osteonecrosis of the femoral head: genetic basis.International orthopaedics · 2019Pooled it
- Pooled it
- Trial
- Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head.Annals of medicine · 2024Review
- MIR31HG polymorphisms are related to steroid-induced osteonecrosis of femoral head among Chinese Han population.BMC musculoskeletal disorders · 2022Article
- Association of Specific Genetic Polymorphisms with Atraumatic Osteonecrosis of the Femoral Head: A Narrative Review.Indian journal of orthopaedics · 2022Review
- Steroid-induced osteonecrosis.Journal of translational autoimmunity · 2022Review
- Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head.Journal of orthopaedic surgery and research · 2021Article
- ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head.Journal of Korean medical science · 2021Review
- Variants in RETN gene are associated with steroid-induced osteonecrosis of the femoral head risk among Han Chinese people.Journal of orthopaedic surgery and research · 2020Article
- MMP-14 single-nucleotide polymorphisms are related to steroid-induced osteonecrosis of the femoral head in the population of northern China.Molecular genetics & genomic medicine · 2019Article
- Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head.Drug design, development and therapy · 2019Article
- The relationship between genetic polymorphisms in apolipoprotein E (ApoE) gene and osteonecrosis of the femoral head induced by steroid in Chinese Han population.Genes & genomics · 2018Article
- Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head.Cell proliferation · 2018Article
- Emerging roles of MicroRNAs in osteonecrosis of the femoral head.Cell proliferation · 2018Review
- Article
- Differential expression of miR-195-5p in collapse of steroid-induced osteonecrosis of the femoral head.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.