Evidence map›Paper›PMID 27636898›Full record

ArticlePediatric research2017

Enduring disturbances in regional cerebral blood flow and brain oxygenation at 24 h after asphyxial cardiac arrest in developing rats.

Lesley M Foley, Robert S B Clark, Alberto L Vazquez, T Kevin Hitchens, Henry Alexander, Chien Ho, Patrick M Kochanek, Mioara D Manole

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Cerebral ischemia in the developing brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lesley M FoleyAnimal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Robert S B ClarkDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Alberto L VazquezAnimal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
T Kevin HitchensAnimal Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Henry AlexanderDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Chien HoDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Patrick M KochanekDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Mioara D ManoleDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
University of Pittsburgh · USImaging Center · USCarnegie Mellon University · US

Funding

Mitochondria-Targeted Redox Therapy for Cerebral Ischemia in the Developing BrainR01NS084604 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA, CLARK, ROBERT S B · 2014 to 2018
$2.0M
Excitatory and Inhibitory Activity Contributions to Hemodynamic SignalsR01NS094404 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAZQUEZ, ALBERTO L · 2016 to 2020
$1.7M
CYP 450-mediated CBF Dysregulation and Neurotoxicity in Pediatric Cardiac ArrestR01HD075760 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANOLE, MIOARA D. · 2013 to 2017
$1.5M
Functional relationship between neural, metabolic and hemodynamic responsesK01NS066131 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAZQUEZ, ALBERTO L · 2010 to 2014
$617k
NICHD NIH HHS R01 HD075760NINDS NIH HHS K01 NS066131NINDS NIH HHS R01 NS084604NINDS NIH HHS R01 NS094404
6 · The paper itself

Abstract

backgroundDisturbances in cerebral blood flow (CBF) and brain oxygenation (PbO

methodsRegional CBF and PbO

resultsIn all regions but the thalamus, CBF recovered to sham values by 24 h; thalamic CBF was >32% higher after CA vs. sham. PbO

conclusionCBF remains increased in the thalamus at 24 h after CA and PbO

Indexed as

AnimalsAsphyxiaBrainCerebral CortexCerebrovascular CirculationDisease Models, AnimalHeart ArrestHypoxiaMaleOxygenOxygen ConsumptionRatsRats, Sprague-DawleyThalamusOxygen

Identifiers

PMID27636898
PMCPMC5287715
OpenAlexW2519818764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.