Evidence map›Paper›PMID 27636893›Full record

ArticleJournal of cellular physiology2017

A MicroRNA Cluster miR-23-24-27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport.

Xiaoning Liu, Robert S Edinger, Christine A Klemens, Yu L Phua, Andrew J Bodnar, William A LaFramboise, Jacqueline Ho, Michael B Butterworth

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Non-coding RNAs and the mineralocorticoid receptor in the kidney.Molecular and cellular endocrinology · 2021
    Review
  7. Article
  8. Aldosterone-induced microRNAs act as feedback regulators of mineralocorticoid receptor signaling in kidney epithelia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  9. Review
  10. The Role of MicroRNA in the Airway Surface Liquid Homeostasis.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Article
  13. ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoning LiuDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Robert S EdingerDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Christine A KlemensDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yu L PhuaDivision of Nephrology in the Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Andrew J BodnarDivision of Nephrology in the Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
William A LaFramboiseDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Jacqueline HoDivision of Nephrology in the Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Michael B ButterworthDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of MicroRNAs in Kidney Sodium RegulationR01DK102843 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERWORTH, MICHAEL B · 2015 to 2024
$3.6M
The Role of miR-17~92 in Nephron ProgenitorsR01DK103776 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2014 to 2018
$1.7M
MicroRNAs in Kidney Progenitor Cells.R00DK087922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2012 to 2014
$722k
NCI NIH HHS P30 CA047904NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R00 DK087922NIDDK NIH HHS R01 DK102843NIDDK NIH HHS R01 DK103776NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

The epithelial sodium channel (ENaC) is expressed in the epithelial cells of the distal convoluted tubules, connecting tubules, and cortical collecting duct (CCD) in the kidney nephron. Under the regulation of the steroid hormone aldosterone, ENaC is a major determinant of sodium (Na

Indexed as

3' Untranslated RegionsAdaptor Proteins, Vesicular TransportAldosteroneAnimalsBiological TransportEpithelial CellsEpithelial Sodium ChannelsKidney Tubules, CollectingMice, Inbred C57BLMicroRNAsNephronsProtein BindingRibonuclease IIIRNA, MessengerSignal TransductionSodium3' Untranslated RegionsAdaptor Proteins, Vesicular TransportAldosteroneEpithelial Sodium ChannelsItsn2 protein, mouseMicroRNAsMirn23b microRNA, mouseMirn24 microRNA, mouseMirn27 microRNA, mouseRibonuclease IIIRNA, MessengerSodium

Identifiers

PMID27636893
PMCPMC5426511
OpenAlexW2522000325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.