ArticleTranscription2016
tRNA evolution from the proto-tRNA minihelix world.
Article in Transcription, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Resurrecting tRNAs of the Last Universal Common Ancestor (Commonote) Toward Rebuilding the Ancient Translation System.Journal of molecular evolution · 2026Article
- Review
- Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs).Life (Basel, Switzerland) · 2026Review
- Information Gradient among Nucleotide Sequences of Essential RNAs from an Evolutionary Perspective.International journal of molecular sciences · 2024Article
- A Proposal of the Ur-RNAome.Genes · 2023Article
- The 3 31 Nucleotide Minihelix tRNA Evolution Theorem and the Origin of Life.Life (Basel, Switzerland) · 2023Review
- Investigation of tRNA-based relatedness within the Planctomycetes-Verrucomicrobia-Chlamydiae (PVC) superphylum: a comparative analysis.Archives of microbiology · 2023Article
- Primitive Oligomeric RNAs at the Origins of Life on Earth.International journal of molecular sciences · 2023Article
- Self-empowerment of life through RNA networks, cells and viruses.F1000Research · 2023Review
- Structural Computational Analysis of the Natural History of Class I aminoacyl-tRNA Synthetases Suggests their Role in Establishing the Genetic Code.Journal of molecular evolution · 2021Article
- Menzerath-Altmann's Law of Syntax in RNA Accretion History.Life (Basel, Switzerland) · 2021Article
- Evolution of the genetic code.Transcription · 2021Review
- Universal Codons with Enrichment from GC to AU Nucleotide Composition Reveal a Chronological Assignment from Early to Late Along with LUCA Formation.Life (Basel, Switzerland) · 2020Article
- Genome-wide analysis revealed novel molecular features and evolution of Anti-codons in cyanobacterial tRNAs.Saudi journal of biological sciences · 2020Article
- RNA Rings Strengthen Hairpin Accretion Hypotheses for tRNA Evolution: A Reply to Commentaries by Z.F. Burton and M. Di Giulio.Journal of molecular evolution · 2020Article
- Debating tRNA Origins.Journal of molecular evolution · 2020Article
- Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides.Life (Basel, Switzerland) · 2019Article
- What viruses tell us about evolution and immunity: beyond Darwin?Annals of the New York Academy of Sciences · 2019Review
- The Origin of tRNA Deduced from Pseudomonas aeruginosa 5' Anticodon-Stem Sequence : Anticodon-stem loop hypothesis.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2019Article
- A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code.Life (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple models have been advanced for the evolution of cloverleaf tRNA. Here, the conserved archaeal tRNA core (75-nt) is posited to have evolved from ligation of three proto-tRNA minihelices (31-nt) and two-symmetrical 9-nt deletions within joined acceptor stems (93 - 18 = 75-nt). The primary evidence for this conclusion is that the 5-nt stem 7-nt anticodon loop and the 5-nt stem 7-nt T loop are structurally homologous and related by coding sequence. We posit that the D loop was generated from a third minihelix (31-nt) in which the stem and loop became rearranged after 9-nt acceptor stem deletions and cloverleaf folding. The most 3´-5-nt segment of the D loop and the 5-nt V loop are apparent remnants of the joined acceptor stems (14 - 9 = 5-nt). Before refolding in the tRNA cloverleaf, we posit that the 3'-5-nt segment of the D loop and the 5-nt V loop were paired, and, in the tRNA cloverleaf, frequent pairing of positions 29 (D loop) and 47 (V loop) remains (numbered on a 75-nt tRNA cloverleaf core). Amazingly, after >3.5 billion years of evolutionary pressure on the tRNA cloverleaf structure, a model can be constructed that convincingly describes the genesis of 75/75-nt conserved archaeal tRNA core positions. Judging from the tRNA structure, cloverleaf tRNA appears to represent at least a second-generation scheme (and possibly a third-generation scheme) that replaced a robust 31-nt minihelix protein-coding system, evidence for which is preserved in the cloverleaf structure. Understanding tRNA evolution provides insights into ribosome and rRNA evolution.
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