Evidence map›Paper›PMID 27636250›Full record

ArticleJournal of computer assisted tomography

Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers.

Farbod N Rahaghi, J Michael Wells, Carolyn E Come, Isaac A De La Bruere, Surya P Bhatt, James C Ross, Gonzalo Vegas-Sánchez-Ferrero, Alejandro A Diaz, Jasleen Minhas, Mark T Dransfield and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Contributions of Emphysema and Functional Small Airway Disease on Intrapulmonary Vascular Volume in COPD.International journal of chronic obstructive pulmonary disease · 2022
    Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort.American journal of respiratory and critical care medicine · 2018
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Farbod N RahaghiFrom the *Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA; †Division of Pulmonary, Allergy and Critical Care Medicine, and ‡UAB Lung Health Center, University of Alabama at Birmingham; and §Birmingham VA Medical Center, Birmingham, AL; and ∥Department of Radiology Harvard School of Medicine Surgical Planning Laboratory, Boston, MA.
J Michael Wells
Carolyn E Come
Isaac A De La Bruere
Surya P Bhatt
James C Ross
Gonzalo Vegas-Sánchez-Ferrero
Alejandro A Diaz
Jasleen Minhas
Mark T Dransfield
Raúl San José Estépar
George R Washko
and the COPDGene Investigators
Birmingham VA Medical Center · USBrigham and Women's Hospital · USUniversity of Alabama at Birmingham · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
The clinical impact of pulmonary vascular remodeling in smokersR01HL116473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL, WASHKO, GEORGE R · 2013 to 2021
$5.0M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
Using Vessel Caliber to Assess Cardiac Impairment in COPDK23HL114735 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI COME, CAROLYN E · 2013 to 2017
$890k
Computed Tomographic-Based Assessment of Airway Remodeling in COPDK01HL118714 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2013 to 2017
$783k
The Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744k
NHLBI NIH HHS K01 HL118714NHLBI NIH HHS K08 HL123940NHLBI NIH HHS K23 HL114735NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL116473NHLBI NIH HHS R01 HL116931NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIH HHS S10 OD018526
6 · The paper itself

Abstract

objectivePrior work has described the relationship between pulmonary vascular pruning on computed tomography (CT) scans and metrics of right-sided heart dysfunction in smokers. In this analysis, we sought to look at pruning on a lobar level, as well as examine the effect of the arterial and venous circulation on this association.

methodsAutomated vessel segmentation applied to noncontrast CT scans from the COPDGene Study in 24 subjects with cardiac magnetic resonance imaging scans was used to create a blood volume distribution profile. These vessels were then manually tracked to their origin and characterized as artery or vein.

resultsAssessment of pruning on a lobar level revealed associations between pruning and right ventricular function previously not observed on a global level. The right ventricular mass index, the right ventricular end-systolic volume index, and pulmonary arterial-to-aorta ratio were associated with both arterial and venous pruning, whereas right ventricular ejection fraction was associated with only arterial pruning.

conclusionsLobar assessment and segmentation of the parenchymal vasculature into arterial and venous components provide additional information about the relationship between loss of vasculature on CT scans and right ventricular dysfunction.

Indexed as

BostonFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMultimodal ImagingPrevalencePulmonary ArteryPulmonary VeinsReproducibility of ResultsRisk FactorsSensitivity and SpecificitySmokingVentricular Dysfunction, Right

Identifiers

PMID27636250
PMCPMC5110399
OpenAlexW2520543356

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.