ArticleArthritis care & research2017
Knee Pain and Structural Damage as Risk Factors for Incident Widespread Pain: Data From the Multicenter Osteoarthritis Study.
Article in Arthritis care & research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Synovial Fluid Characteristics and Pain Recovery Trajectory Following Rehabilitation in Patients with Meniscal Tears: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Longitudinal associations between bilateral versus unilateral knee osteoarthritis and physical performance measures.Osteoarthritis and cartilage open · 2025Article
- Associations between knee pain and knee-loading physical activities at work and leisure - a cross-sectional study based on accelerometer measurements.BMC musculoskeletal disorders · 2025Observational
- Association between widespread pain and psychosocial factors in people with knee osteoarthritis: a cross-sectional study of patients from primary care in Denmark.Physiotherapy theory and practice · 2025Article
- The mechanosensitive protein ANTXR1 is involved in maintaining cartilage homeostasis in post-traumatic osteoarthritis.Frontiers in cell and developmental biology · 2025Article
- Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning.Heliyon · 2024Article
- Multiple joint osteoarthritis (MJOA): What's in a name?Osteoarthritis and cartilage · 2024Review
- Factors Associated with Intermittent, Constant, and Mixed Pain in People with Knee Osteoarthritis.Physiotherapy Canada. Physiotherapie Canada · 2022Article
- Comparing the association of widespread pain, multi-joint pain and low back pain with measures of pain sensitization and function in people with knee osteoarthritis.Clinical rheumatology · 2020Article
- Validity of the central sensitization inventory with measures of sensitization in people with knee osteoarthritis.Clinical rheumatology · 2018Article
- Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.Osteoarthritis and cartilage · 2018Article
- Paradigm Shift in Geriatric Low Back Pain Management: Integrating Influences, Experiences, and Consequences.Physical therapy · 2018Review
- Classification of patients with knee osteoarthritis in clinical phenotypes: Data from the osteoarthritis initiative.PloS one · 2018Article
- Accelerated aging in adults with knee osteoarthritis pain: consideration for frequency, intensity, time, and total pain sites.Pain reports · 2017Article
- The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study.The Journal of rheumatology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the longitudinal relationship of knee pain, radiographic osteoarthritis (OA), symptomatic knee OA, and knee pain severity to incident widespread pain.
methodsThe Multicenter Osteoarthritis Study is a longitudinal cohort of persons with or at risk of knee OA. Participants were characterized as having consistent frequent knee pain, radiographic OA (Kellgren/Lawrence scale grade ≥2), symptomatic OA, and knee pain severity at the 60-month visit (baseline). Widespread pain was categorized as pain above and below the waist, on both sides of the body and axially, using a standard homunculus, excluding knee pain. Incident widespread pain was defined as the presence of widespread pain at 84 months in those who were free of widespread pain at baseline. We assessed the relationship of baseline radiographic OA, symptomatic OA, consistent frequent knee pain, and knee pain severity, respectively, with incident widespread pain using logistic regression, adjusting for potential confounders, including models with and without pain severity.
resultsAt baseline, 1,129 subjects were eligible for analysis (mean ± SD age 66.7 ± 7.8 years; mean ± SD body mass index 30.1 ± 5.8 kg/m
conclusionConsistent frequent knee pain, symptomatic OA, and knee pain severity increased the risk of developing widespread pain, independently of structural pathology. These results suggest that knee pain, and not structural pathology, contributes to the onset of widespread pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.