ArticleJournal of computer assisted tomography
Use of Susceptibility-Weighted Imaging (SWI) in the Detection of Brain Hemorrhagic Metastases from Breast Cancer and Melanoma.
Article in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Brain metastases from breast cancer using magnetic resonance imaging: A systematic review.Journal of medical radiation sciences · 2024Pooled it
- Voxel-accurate MRI-microscopy Correlation Enables AI-powered Prediction of Brain Disease States.Theranostics · 2026Article
- Brain metastases from ovarian cancer: neuroradiological profile and survival overview of neurosurgical cases.Journal of neuro-oncology · 2025Observational
- Multiparametric MRI characteristics for differentiating primary cancer origin in brain metastases.BMC medical imaging · 2025Article
- Characterization of brain metastases from lung cancer using percentagewise quantification of intratumoral susceptibility signals.Quantitative imaging in medicine and surgery · 2025Article
- Brain Metastases from Primary Cardiac Tumors: A Systematic Review of Diagnosis, Treatment, and Prognosis.Cancers · 2025Review
- Differentiation Between Radiation Necrosis and True Tumour Progression After Radiotherapy to Intracranial Metastases.Journal of medical imaging and radiation oncology · 2025Review
- Diagnostics and Screening in Breast Cancer with Brain and Leptomeningeal Metastasis: A Review of the Literature.Cancers · 2024Review
- Immunotherapy: an emerging modality to checkmate brain metastasis.Molecular cancer · 2023Review
- Brain metastases: An update on the multi-disciplinary approach of clinical management.Neuro-Chirurgie · 2022Review
- Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis.Frontiers in oncology · 2021Article
- Assessment of Melanin Content and its Influence on Susceptibility Contrast in Melanoma Metastases.Clinical neuroradiology · 2020Article
- Single and simultaneous multiple intracerebral hemorrhages: a radiological review.Acta neurologica Belgica · 2020Review
- Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases.Neuro-oncology · 2020Article
- Clinical Value of Susceptibility Weighted Imaging of Brain Metastases.Frontiers in neurology · 2020Review
- Recognition of Brain Metastases Using Gadolinium-Enhanced SWI MRI: Proof-of-Concept Study.Frontiers in neurology · 2020Article
- Bevacizumab as a steroid-sparing agent during immunotherapy for melanoma brain metastases: A case series.Health science reports · 2019Article
- Brain metastases: neuroimaging.Handbook of clinical neurology · 2018Review
- Sensitivity of different MRI sequences in the early detection of melanoma brain metastases.PloS one · 2018Article
- Susceptibility-Based Neuroimaging: Standard Methods, Clinical Applications, and Future Directions.Current radiology reports · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeSusceptibility-weighted imaging (SWI) has significantly increased our sensitivity in detecting hemorrhagic brain lesions. We sought to explore the prevalence of intratumoral hemorrhage as detected by SWI in brain metastases from melanoma and breast cancer.
methodsLesions with a size of 0.1 cm were categorized as micrometastases, whereas larger lesions were categorized as macrometastases. Susceptibility-weighted imaging findings on locations corresponding to enhancing lesions were categorized as either positive or negative based on presence/absence of signal dropout. The percentage of SWI positivity was then estimated as a function of lesion size. Two-tailed Fisher exact test was performed to examine differences in the contingency tables.
resultsMagnetic resonance imaging studies from 73 patients with 1173 brain metastases, which enhanced on postcontrast T1-weighted imaging (T1WI) were selected for analysis. Of these lesions, 952 had SWI data available, and 342 of 952 were micrometastases. Only 10 of the 342 micrometastases and 410 (67.2%) of the 610 macrometastases were SWI positive (P < 0.0001). When examined by tumor type, 76.9% (melanoma) versus 55.6% (breast cancer) were SWI positive (P < 0.0001), regardless of tumor size. All melanoma lesions (8/8) and only 1 of 15 breast cancer lesions larger than 1.5 cm were SWI positive.
conclusionWith the use of combined SWI and contrast-enhanced high-resolution T1 imaging, we found that presence of intratumoral brain hemorrhage is uncommon in micrometastases but common in metastases greater than 0.1 cm from breast cancer or melanoma. Large metastases commonly harbored hemorrhage, and this occurred more frequently in patients with melanoma than with breast cancer.
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