ArticlePloS one2016
A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Systematic review and meta-analysis of predictive accuracy of prognostic models for poor treatment outcome of drug resistance tuberculosis.Scientific reports · 2026Pooled it
- Systematic review of prediction models for pulmonary tuberculosis treatment outcomes in adults.BMJ open · 2021Pooled it
- Physiologic-Inflammatory-Nutrition (TRIAD-TB) Score at 72 Hours Predicts 30-Day Mortality and Length of Stay in Pulmonary Tuberculosis: A Prospective Cohort Study.Biomedicines · 2025Article
- Development and validation of clinical prediction score for mortality in tuberculosis patients.Narra J · 2025Article
- A predictive score for early in-patient tuberculosis mortality: A case-control study.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Development of prognostic scoring system for predicting 1-year mortality among pulmonary tuberculosis patients in South India.Journal of public health (Oxford, England) · 2023Observational
- Screening for Severe Illness at Diagnosis Has the Potential to Prevent Early TB Deaths: Programmatic Experience From Karnataka, India.Global health, science and practice · 2022Article
- The impact of single-cell genomics on the field of mycobacterial infection.Frontiers in microbiology · 2022Review
- Review
- Risk factors for mortality and multidrug resistance in pulmonary tuberculosis in Guatemala: A retrospective analysis of mandatory reporting.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Article
- Screening People with Tuberculosis for High Risk of Severe Illness at Notification: Programmatic Experience from Karnataka, India.Tropical medicine and infectious disease · 2021Article
- In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors.Journal of clinical tuberculosis and other mycobacterial diseases · 2021Article
- Heterogeneous Streptomycin Resistance Level AmongFrontiers in microbiology · 2021Article
- Tuberculosis deaths are predictable and preventable: Comprehensive assessment and clinical care is the key.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production.Nature communications · 2020Article
- Correction: A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis.PloS one · 2020Article
- Article
- Development and validation of a risk score to predict mortality during TB treatment in patients with TB-diabetes comorbidity.BMC infectious diseases · 2019Article
- Tuberculosis Mortality in the United States: Epidemiology and Prevention Opportunities.Annals of the American Thoracic Society · 2018Article
- A complex scenario of tuberculosis transmission is revealed through genetic and epidemiological surveys in Porto.BMC infectious diseases · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis imposes high human and economic tolls, including in Europe. This study was conducted to develop a severity assessment tool for stratifying mortality risk in pulmonary tuberculosis (PTB) patients. A derivation cohort of 681 PTB cases was retrospectively reviewed to generate a model based on multiple logistic regression analysis of prognostic variables with 6-month mortality as the outcome measure. A clinical scoring system was developed and tested against a validation cohort of 103 patients. Five risk features were selected for the prediction model: hypoxemic respiratory failure (OR 4.7, 95% CI 2.8-7.9), age ≥50 years (OR 2.9, 95% CI 1.7-4.8), bilateral lung involvement (OR 2.5, 95% CI 1.4-4.4), ≥1 significant comorbidity-HIV infection, diabetes mellitus, liver failure or cirrhosis, congestive heart failure and chronic respiratory disease-(OR 2.3, 95% CI 1.3-3.8), and hemoglobin <12 g/dL (OR 1.8, 95% CI 1.1-3.1). A tuberculosis risk assessment tool (TReAT) was developed, stratifying patients with low (score ≤2), moderate (score 3-5) and high (score ≥6) mortality risk. The mortality associated with each group was 2.9%, 22.9% and 53.9%, respectively. The model performed equally well in the validation cohort. We provide a new, easy-to-use clinical scoring system to identify PTB patients with high-mortality risk in settings with good healthcare access, helping clinicians to decide which patients are in need of closer medical care during treatment.
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