Evidence map›Paper›PMID 27636027›Full record

ArticleRadiology2016

Coronary CT Angiography: Variability of CT Scanners and Readers in Measurement of Plaque Volume.

Rolf Symons, Justin Z Morris, Colin O Wu, Amir Pourmorteza, Mark A Ahlman, João A C Lima, Marcus Y Chen, Marissa Mallek, Veit Sandfort, David A Bluemke

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06029387 (Artificial Intelligence for Preventing Heart Disease), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06029387 completednot on this mapstarted 2023, after this paper: background citation

Artificial Intelligence for Preventing Heart Disease: Observational, Single Center, Prospective and Retrospective Study

TypeobservationalSponsorIRCCS San RaffaeleRan2023 to 2024Enrolled3,000ConditionsCoronary Artery Disease
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  9. Article
  10. The Role of Cardiac Computed Tomography Angiography in Risk Stratification for Coronary Artery Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rolf SymonsFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).ORCID http://orcid.org/0000-0001-7889-6773
Justin Z MorrisFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
Colin O WuFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
Amir PourmortezaFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).ORCID http://orcid.org/0000-0001-7149-5424
Mark A AhlmanFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
João A C LimaFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
Marcus Y ChenFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
Marissa MallekFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
Veit SandfortFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).
David A BluemkeFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10, Room 1C355, Bethesda, MD 20892 (R.S., J.Z.M., A.P., M.A.A., M.M., V.S., D.A.B.); Office of Biostatistics Research (C.O.W.) and Cardiovascular and Pulmonary Branch (M.Y.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md (J.A.C.L.).

Funding

Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Molecular Biomedical Imaging Laboratory (CC)ZIACL090019 · CLC · CLINICAL CENTER · PI JONES, ELIZABETH C. · 2010 to 2017
$0k
Intramural NIH HHS ZIA CL090019Intramural NIH HHS ZIA EB000072
6 · The paper itself

Abstract

Purpose To determine reader and computed tomography (CT) scan variability for measurement of coronary plaque volume. Materials and Methods This HIPAA-compliant study followed Standards for Reporting of Diagnostic Accuracy guidelines. Baseline coronary CT angiography was performed in 40 prospectively enrolled subjects (mean age, 67 years ± 6 [standard deviation]) with asymptomatic hyperlipidemia by using a 320-detector row scanner (Aquilion One Vision; Toshiba, Otawara, Japan). Twenty of these subjects underwent coronary CT angiography repeated on a separate day with the same CT scanner (Toshiba, group 1); 20 subjects underwent repeat CT performed with a different CT scanner (Somatom Force; Siemens, Forchheim, Germany [group 2]). Intraclass correlation coefficients (ICCs) and Bland-Altman analysis were used to assess interreader, intrareader, and interstudy reproducibility. Results Baseline and repeat coronary CT angiography scans were acquired within 19 days ± 6. Interreader and intrareader agreement rates were high for total, calcified, and noncalcified plaques for both CT scanners (all ICCs ≥ 0.96) without bias. Scanner variability was ±18.4% (coefficient of variation) with same-vendor follow-up. However, scanner variability increased to ±29.9% with different-vendor follow-up. The sample size to detect a 5% change in noncalcified plaque volume with 90% power and an α error of .05 was 286 subjects for same-CT scanner follow-up and 753 subjects with different-vendor follow-up. Conclusion State-of-the-art coronary CT angiography with same-vendor follow-up has good scan-rescan reproducibility, suggesting a role of coronary CT angiography in monitoring coronary artery plaque response to therapy. Differences between coronary CT angiography vendors resulted in lower scan-rescan reproducibility.

Indexed as

AgedAged, 80 and overComputed Tomography AngiographyCoronary Artery DiseaseHumansMiddle AgedObserver VariationPlaque, AtheroscleroticTomography Scanners, X-Ray Computed

Identifiers

PMID27636027
PMCPMC5131836

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.