ArticleAutophagy2016
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.
Open access · hybridAbstract read
In one paragraph
Article in Autophagy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
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- Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer.Journal of cellular and molecular medicine · 2025Article
- Comprehensive Identification of Lipid-Membrane Protein Interactions via Advanced Proteomics and Extended Lipid-Immobilized Bead Technology.Analytical chemistry · 2025Article
- The inducible role of autophagy in cell death: emerging evidence and future perspectives.Cell communication and signaling : CCS · 2025Review
- Bioactive Compounds Targeting Dihydroceramide and Their Therapeutic Potential in Cancer Treatment.Cancers · 2025Review
- The Endocannabinoid System: Implications in Gastrointestinal Physiology and Pathology.International journal of molecular sciences · 2025Review
- Golgi-derived extracellular vesicle production induced by SARS-CoV-2 envelope protein.Apoptosis : an international journal on programmed cell death · 2025Article
- Potential mechanism of traditional Chinese medicine intervention in gastric cancer: targeted regulation of autophagy.Frontiers in pharmacology · 2025Review
- Signatures of Six Autophagy-Related Genes as Diagnostic Markers of Thyroid-Associated Ophthalmopathy and Their Correlation With Immune Infiltration.Immunity, inflammation and disease · 2024Article
- Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells.Redox biology · 2024Article
- Cannabinoids in the treatment of glioblastoma.Pharmacological reports : PR · 2024Review
- The potential protective and therapeutic effects of cannabidiol oil on experimental Leukemia induced by DMBA in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Emerging Lipid Targets in Glioblastoma.Cancers · 2024Review
- Therapeutic Potential of Ceramide in Cancer Treatment.Journal of cancer research and oncobiology · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 11 institutions in 4 countries.
Sonia Hernández-Tiedraa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Gemma Fabriàsc Research Unit on BioActive Molecules (RUBAM) , Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) , Barcelona , Spain.
David Dávilaa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Íñigo J Salanuevaa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Josefina Casasc Research Unit on BioActive Molecules (RUBAM) , Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) , Barcelona , Spain.
L Ruth Montesd Biofisika Institute (UPV/EHU, CSIC) , and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n , Leioa , Spain.
Zuriñe Antónd Biofisika Institute (UPV/EHU, CSIC) , and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n , Leioa , Spain.
Elena García-Taboadaa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
María Salazar-Roaa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Mar Lorentea Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Jesper Nylandstede Unit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC) , Copenhagen , Denmark.
Jane Armstrongf Dermatological Sciences , Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne , UK.
Israel López-Valeroa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Christopher S McKeef Dermatological Sciences , Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne , UK.
Ana Serrano-Pueblaa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Roberto García-Lópeza Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
José González-Martíneza Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
José L Abadc Research Unit on BioActive Molecules (RUBAM) , Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) , Barcelona , Spain.
Kentaro Hanadai Department of Biochemistry and Cell Biology , National Institute of Infectious Diseases , Shinjuku-ku, Tokyo , Japan.
Patricia Boyah Departament of Cellular and Molecular Biology , Centro de Investigaciones Biológicas, CSIC , Madrid , Spain.
Félix Goñid Biofisika Institute (UPV/EHU, CSIC) , and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n , Leioa , Spain.
Manuel Guzmána Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Penny Lovatf Dermatological Sciences , Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne , UK.
Marja Jäätteläe Unit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC) , Copenhagen , Denmark.
Alicia Alonsod Biofisika Institute (UPV/EHU, CSIC) , and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n , Leioa , Spain.
Guillermo Velascoa Department of Biochemistry and Molecular Biology I , School of Biology, Complutense University , Madrid , Spain.
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESUniversidad Complutense de Madrid · ESInstitute of Advanced Chemistry of Catalonia · ESUniversity of the Basque Country · ESCentro de Investigaciones Biológicas Margarita Salas · ESDanish Cancer Society · DKNewcastle University · GBBiofisika · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESNational Institute of Infectious Diseases · JPUniversity of Sunderland · GB
Funding
European Research Council 340751
Abstract
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ
Indexed as
ApoptosisAutophagyBiological TransportCell Line, TumorCell ProliferationCeramidesDronabinolEndoplasmic ReticulumGolgi ApparatusHumansIntracellular MembranesLysosomesModels, BiologicalNeoplasmsPermeabilityPhagosomesCeramidesdihydroceramideDronabinolSphingolipidsautophagycancercannabinoidscell deathsphingolipids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.