ArticleAmerican journal of respiratory and critical care medicine2017
Recovery after Acute Kidney Injury.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 280 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vasopressin on Kidney and Cardiac Function in Previously Hypertensive Patients With Septic Shock: A Randomized Clinical Trial
Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.
Who cites it
280 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Methods for phenotyping adult patients with acute kidney injury: a systematic review.Journal of nephrology · 2025Pooled it
- Effects of early recovery of renal function on adverse renal outcomes and mortality in patients with acute kidney injury: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Effect of care bundles for acute kidney injury: A systematic review and meta-analysis.PloS one · 2024Pooled it
- A Systematic Bibliometric Analysis of High-Impact Articles in Critical Care Nephrology.Blood purification · 2024Pooled it
- Trial
- Open-label, controlled, phase 2 clinical trial assessing the safety, efficacy, and pharmacokinetics of INM004 in pediatric patients with Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2025Trial
- Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial.Intensive care medicine · 2022Trial
- Clinical practice guideline for renal replacement therapy in critically ill patients with acute kidney injury (2026 edition).Journal of intensive medicine · 2026Article
- Biochemical phenotypes of acute kidney injury and their association with major adverse kidney events.Renal failure · 2026Article
- PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Diagnostic accuracy of the blood urea-to-creatinine ratio for differentiating AKI etiologies and dialysis prediction in adults: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2026Article
- Implementation of the kidney protection strategy in critically ill patients with acute kidney injury - a multi-center prospective cohort study.Critical care (London, England) · 2026Article
- Deep-learning time-series anomaly detection of acute kidney injury from creatinine-eGFR trajectories in the ICU.PLOS digital health · 2026Article
- Impact of Early Allograft Dysfunction on Renal Function Outcomes Following Liver Transplantation.Medicina (Kaunas, Lithuania) · 2026Article
- Short- and long-term outcomes of elderly patients with acute kidney injury to acute kidney disease.Journal of intensive care · 2026Article
- Efficacy of cilastatin sodium in a translational large animal crush syndrome model.Communications medicine · 2026Article
- Deep learning approaches for time series prediction of renal recovery in medical critically Ill patients with acute kidney injury: LSTM, GRU, and transformer models.Critical care (London, England) · 2026Article
- Pathophysiology and Management of Sepsis-associated Acute Kidney Injury.Clinics in chest medicine · 2026Review
- The global epidemiology of acute kidney injury: challenges and opportunities.Nature reviews. Nephrology · 2026Review
- Predicting and Modeling Recovery Dynamics Post-Acute Kidney Injury: A Multicenter Study.Kidney360 · 2026Article
220 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
rationaleLittle is known about how acute kidney injury (AKI) resolves, and whether patterns of reversal of renal dysfunction differ among patients with respect to ultimate recovery.
objectivesWe sought to examine different patterns for AKI reversal that are found in patients and assess how they relate to postdischarge outcomes.
methodsWe studied 16,968 critically ill patients with Kidney Disease Improving Global Outcomes stage 2 or 3 AKI, using an electronic database. Reversal of AKI was defined as alive and no longer meeting criteria for even stage 1. Recovery was defined as reversal at hospital discharge. MEASUREMENTS AND MAIN
resultsWe observed five patterns. The most common (4,508; 26.6%) was early reversal that was sustained through discharge, but almost as many patients (4,496; 26.5%) had no reversal at all. The remaining patients had late reversal after Day 7 (9.7%); early reversal with one or more relapses, but with ultimate recovery (22.5%); and relapsing without recovery (14.7%). Outcomes for patients with these phenotypes were quite different, with age-adjusted 1-year survival varying from more than 90% for early reversal to less than 40% for patients never reversing. Relapses are common (37.3%), especially in the first 72 hours after reversal, and are associated with a fivefold increased risk for death by 1 year compared with early sustained reversal.
conclusionsWe have identified five distinct recovery phenotypes on the basis of the clinical course over the first week after AKI manifestation. These phenotypes may identify patients amenable to therapeutic intervention. Long-term outcomes are associated with recovery status at hospital discharge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.