ArticleeLife2016
Spatiotemporal interplay between multisensory excitation and recruited inhibition in the lamprey optic tectum.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- stTransfer enables transfer of single-cell annotations to spatial transcriptomics with single-cell resolution.Cell reports methods · 2025Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Different Types of Connections Between the Thalamus and Vestibular Nucleus in the Human Brain.Journal of clinical medicine · 2025Article
- Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus.PLoS biology · 2025Article
- Single-nucleus profiling decoding the subcortical visual pathway evolution of vertebrates.iScience · 2025Article
- Article
- Direct retino-iridal projections and intrinsic iris contraction mediate the pupillary light reflex in early vertebrates.Communications biology · 2024Article
- Spatial and single-nucleus transcriptomics decoding the molecular landscape and cellular organization of avian optic tectum.iScience · 2024Article
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Unravelling the functional development of vertebrate pathways controlling gaze.Frontiers in cell and developmental biology · 2023Article
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Conserved subcortical processing in visuo-vestibular gaze control.Nature communications · 2022Article
- Morphology and Dendrite-Specific Synaptic Properties of Midbrain Neurons Shape Multimodal Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The neural bases of vertebrate motor behaviour through the lens of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The Dopaminergic Control of Movement-Evolutionary Considerations.International journal of molecular sciences · 2021Review
- The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.Current biology : CB · 2021Review
- Consciousness in Jawless Fishes.Frontiers in systems neuroscience · 2021Article
- Using superior colliculus principles of multisensory integration to reverse hemianopia.Neuropsychologia · 2020Article
- Clearing techniques for visualizing the nervous system in development, injury, and disease.Journal of neuroscience methods · 2020Review
- The role of the optic tectum for visually evoked orienting and evasive movements.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals integrate the different senses to facilitate event-detection for navigation in their environment. In vertebrates, the optic tectum (superior colliculus) commands gaze shifts by synaptic integration of different sensory modalities. Recent works suggest that tectum can elaborate gaze reorientation commands on its own, rather than merely acting as a relay from upstream/forebrain circuits to downstream premotor centers. We show that tectal circuits can perform multisensory computations independently and, hence, configure final motor commands. Single tectal neurons receive converging visual and electrosensory inputs, as investigated in the lamprey - a phylogenetically conserved vertebrate. When these two sensory inputs overlap in space and time, response enhancement of output neurons occurs locally in the tectum, whereas surrounding areas and temporally misaligned inputs are inhibited. Retinal and electrosensory afferents elicit local monosynaptic excitation, quickly followed by inhibition via recruitment of GABAergic interneurons. Multisensory inputs can thus regulate event-detection within tectum through local inhibition without forebrain control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.