ArticleMaxillofacial plastic and reconstructive surgery2016
S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection.
Article in Maxillofacial plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Botulinum toxin-induced masseter muscle atrophy is associated with impaired autophagic flux without signs of apoptosis in mice.Cell death discovery · 2026Article
- Examination of Information Quality on Public Instagram Profiles Regarding Botulinum Toxin for Bruxism: A Study in São Paulo State, Brazil.Journal of clinical and experimental dentistry · 2024Article
- Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model.Journal of orthopaedic translation · 2020Article
- Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats.Maxillofacial plastic and reconstructive surgery · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).
methodsWe injected either 5 or 10 U of BTX-A into both masseter muscle of rats. As a control group, the same volume of saline was injected. After 14 days, the animals were sacrificed. Subsequently, a biopsy and immunohistochemical staining of the samples were performed using a p65 or S100 antibody.
resultsThe cross-sectional area of each myofibril was significantly reduced by BTX-A injection (
conclusionsThe injection of BTX-A into the masseter muscle induced muscle atrophy. Subsequently, p65 and S100 expression in myoblasts were increased for the protection of muscle cells.
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