Evidence map›Paper›PMID 27635311›Full record

ArticlePeerJ2016

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.

Phillip Lord, Rachel Spiering, Juan C Aguillon, Amy E Anderson, Silke Appel, Daniel Benitez-Ribas, Anja Ten Brinke, Femke Broere, Nathalie Cools, Maria Cristina Cuturi and 23 more

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  4. Tolerogenic dendritic cells generatedFrontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 13 countries.

Phillip Lord *School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
Rachel SpieringInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Juan C AguillonInstituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile.
Amy E AndersonInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Silke AppelBroegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Daniel Benitez-RibasDepartment of Immunology, Hospital Clínic i Provincial and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
Anja Ten BrinkeDepartment of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
Femke BroereFaculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.
Nathalie CoolsLaboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Maria Cristina CuturiCenter for Research in Transplantation and Immunology, ITUN, Inserm UMRS 1064, Nantes, France.
Julie DibollInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Edward K GeisslerDepartment of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
Nick GiannoukakisInstitute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States of America.
Silvia GregoriSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
S Marieke van HamDepartment of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
Staci LattimerSchool of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
Lindsay MarshallSchool of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom.
Rachel A HarryInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
James A HutchinsonDepartment of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
John D IsaacsInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Irma JoostenDepartment of Laboratory Medicine, Radboud University medical center, Nijmegen, The Netherlands.
Cees van KootenDepartment of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.
Ascension Lopez Diaz de CerioArea of Cell Therapy, University Clinic of Navarra, Pamplona, Spain.
Tatjana NikolicDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
Haluk Barbaros OralDepartment of Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey.
Ljiljana Sofronic-MilosavljevicInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Belgrade, Serbia.
Thomas RitterRegenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
Paloma RiquelmeDepartment of Surgery, Section of Experimental Surgery, University Hospital Regensburg, Regensburg, Germany.
Angus W ThomsonThomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
Massimo TruccoInstitute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States of America.
Marta Vives-PiImmunology Division, Germans Trias i Pujol University Hospital and Health Sciences Research Institute, Badalona, Spain.
Eva M Martinez-CaceresImmunology Division, Germans Trias i Pujol University Hospital and Health Sciences Research Institute, Badalona, Spain.
Catharien M U Hilkens *Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Newcastle University · GBUniversity Hospital Regensburg · DEAllegheny Health Network · USLeiden University · NLSanquin · NLBursa Uludağ Üni̇versi̇tesi̇ · TRCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESClinica Universidad de Navarra · ESInserm · FRInstituto de Salud Carlos III · ESOllscoil na Gaillimhe – University of Galway · IERadboud University Medical Center · NLThe San Raffaele Telethon Institute for Gene Therapy · ITUniversitat Autònoma de Barcelona · ESUniversity of Antwerp · BEUniversity of Belgrade · RSUniversity of Bergen · NOUniversity of Chile · CLUniversity of Pittsburgh · USUtrecht University · NL

Funding

Medical Research Council G1001518Versus Arthritis 18155
6 · The paper itself

Abstract

Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.

Indexed as

Antigen-presenting cellsAutoimmune diseaseCell therapyMinimum information modelRegulatory macrophagesReporting guidelinesTolerogenic dendritic cellsTransplantation

Identifiers

PMID27635311
PMCPMC5012269
OpenAlexW2518169008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.