ArticlePeerJ2016
Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review on Metal Dynamics and Marine Toxicity Risk Assessment Using Crustaceans as Bioindicators.Biological trace element research · 2022Pooled it
- In Vivo Bioimaging of Mercury Sulfide Nanoparticles Dissolution in the Gut Environment of Zooplankton.ACS nano · 2026Article
- Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Pharmacology, Toxicology, and Rational Application of Cinnabar, Realgar, and Their Formulations.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Mercury in neonatal and juvenile blacktip sharks (Carcharhinus limbatus). Part I: exposure assessment.Ecotoxicology (London, England) · 2021Article
- Metal concentrations in coastal sharks from The Bahamas with a focus on the Caribbean Reef shark.Scientific reports · 2021Article
- Dredging Activities Carried Out in a Brazilian Estuary Affect Mercury Levels in Swimming Crabs.International journal of environmental research and public health · 2020Article
- Melatonin Protects Rabbit Somatic Cell Nuclear Transfer (SCNT) Embryos from Electrofusion Damage.Scientific reports · 2020Article
- Human health risks of Hg, As, Mn, and Cr through consumption of fish, Ticto barb (Puntius ticto) from a tropical river, Bangladesh.Environmental science and pollution research international · 2018Article
- Influence of Speciation of Thorium on Toxic Effects to Green Algae Chlorella pyrenoidosa.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined developmental toxicity of different mercury compounds, including some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 µM concentrations of MeHg, HgCl2, α-HgS (Zhu Sha), and β-HgS (Zuotai) from stage 10 (6-7 hpf) to 10 days post fertilization (dpf). Of the forms of mercury in this study, the organic form (MeHg) proved the most toxic followed by inorganic mercury (HgCl2), both producing embryo developmental toxicity. Altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. Both α-HgS and β-HgS were less toxic than MeHg and HgCl2. Total RNA was extracted from survivors three days after exposure to MeHg (0.1 µM), HgCl2 (1 µM), α-HgS (10 µM), or β-HgS (10 µM) to examine toxicity-related gene expression. MeHg and HgCl2 markedly induced metallothionein (MT) and heme oxygenase-1 (Ho-1), while α-HgS and β-HgS failed to induce either gene. Chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity.
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Registered trials
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