Evidence map›Paper›PMID 27635086›Full record

Trial reportCirculation research2016

Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience.

Charles H Cunningham, Justin Y C Lau, Albert P Chen, Benjamin J Geraghty, William J Perks, Idan Roifman, Graham A Wright, Kim A Connelly

3 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 230 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02648009 phase1recruitingnot on this map

Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2016 to 2027Enrolled112ConditionsHypertension, HypertrophyArmsHyperpolarized (13) Pyruvate Injection, Gadolinium
NCT03480594 completednot on this mapstarted 2018, after this paper: background citation

Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2018 to 2023Enrolled22ConditionsFatty LiverArmsMRI Tracer
NCT06054516 recruitingnot on this mapstarted 2023, after this paper: background citation

Hyperpolarized MRSI in Ischemic Heart Disease: Metabolic Profiling of the Myocardium

TypeobservationalSponsorHenrik WiggersRan2023 to 2027Enrolled15ConditionsIschemic Heart DiseaseArms13C-enriched pyruvate
3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Exploring Limits of [1-Small science · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Over four minutes of pyruvate TNature communications · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Imaging of metabolic dysfunction in genetic cardiomyopathies.The international journal of cardiovascular imaging · 2025
    Review
  18. Article
  19. Hyperpolarized [1-Journal of magnetic resonance open · 2025
    Article
  20. Article

170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Charles H CunninghamFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C). chuck@sri.utoronto.ca.
Justin Y C LauFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
Albert P ChenFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
Benjamin J GeraghtyFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
William J PerksFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
Idan RoifmanFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
Graham A WrightFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).
Kim A ConnellyFrom the Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); Medical Biophysics, University of Toronto, ON, Canada (C.H.C., J.Y.C.L., B.J.G., G.A.W.); GE Healthcare, Toronto, ON, Canada (A.P.C.); Pharmacy (W.J.P.) and Schulich Heart Program (I.R., G.A.W.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada; and Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada (K.A.C).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAltered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism.

objectiveTo demonstrate the first hyperpolarized METHODS AND

resultsFour healthy subjects underwent conventional proton cardiac magnetic resonance imaging followed by

conclusionsThese results represent the first CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02648009.

Indexed as

AdultCarbon IsotopesHeartHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumPyruvic AcidCarbon IsotopesPyruvic Acidheart failuremagnetic resonance imagingmetabolic imagingmetabolismmitochondria

Identifiers

PMID27635086
PMCPMC5102279

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.