ArticleGenome biology and evolution2016
Reptile Pregnancy Is Underpinned by Complex Changes in Uterine Gene Expression: A Comparative Analysis of the Uterine Transcriptome in Viviparous and Oviparous Lizards.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Genome-Wide Mining of lncRNAs Reveals Their Potential Regulatory Role in the Evolution of Viviparity.Integrative zoology · 2026Article
- Gene Expression and Alternative Splicing Throughout the Reproductive Cycle of a Viviparous Lizard Reveal Novel Genes for Pregnancy and Convergence With Squamates and Mammals.Molecular ecology · 2026Article
- A genome assembly and annotation for the Australian alpine skink Bassiana duperreyi using long-read technologies.G3 (Bethesda, Md.) · 2025Article
- Gene expression profile analysis of subregions of the adult female reproductive tract in the brown anole, Anolis sagrei.Reproduction (Cambridge, England) · 2024Article
- Comparing the potential for maternal-fetal signalling in oviparous and viviparous lizards.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Embryonic specializations for vertebrate placentation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Understanding the evolution of viviparity using intraspecific variation in reproductive mode and transitional forms of pregnancy.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Different Genes are Recruited During Convergent Evolution of Pregnancy and the Placenta.Molecular biology and evolution · 2022Article
- Inflammation and convergent placenta gene co-option contributed to a novel reproductive tissue.Current biology : CB · 2022Article
- A comparison of uterine contractile responsiveness to arginine vasopressin in oviparous and viviparous lizards.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Endometrial recognition of pregnancy occurs in the grey short-tailed opossum ( Monodelphis domestica).Proceedings. Biological sciences · 2019Article
- Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo.Scientific reports · 2018Article
- Recent advances in understanding evolution of the placenta: insights from transcriptomics.F1000Research · 2018Review
- Embryo implantation evolved from an ancestral inflammatory attachment reaction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of new organs is difficult to study because most vertebrate organs evolved only once, more than 500 million years ago. An ideal model for understanding complex organ evolution is the placenta, a structure that is present in live bearing reptiles and mammals (amniotes), which has evolved independently more than 115 times. Using transcriptomics, we characterized the uterine gene expression patterns through the reproductive cycle of a viviparous skink lizard, Pseudemoia entrecasteauxii Then we compare these patterns with the patterns of gene expression from two oviparous skinks Lampropholis guichenoti and Lerista bougainvillii While thousands of genes are differentially expressed between pregnant and non-pregnant uterine tissue in the viviparous skink, few differentially expressed genes were identified between gravid and non-gravid oviparous skinks. This finding suggests that in P. entrecasteauxii, a pregnant-specific gene expression profile has evolved, allowing for the evolution of pregnancy-specific innovations in the uterus. We find substantial gene expression differences between the uterus of the chorioallantoic and the yolk sac placenta in P. entrecasteauxii, suggesting these placental regions are specialized for different placental functions. In particular, the chorioallantoic placenta is likely a major site of nutrient transport by membrane-bound transport proteins, while the yolk sac placenta also likely transports nutrients but via apocrine secretions. We discuss how the evolution of transcription factor networks is likely to underpin the evolution of the new transcriptional states in the uterine tissue of viviparous reptiles.
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