ReviewNutrition reviews2016
Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application.
Open access · bronzeAbstract readReview
In one paragraph
Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Clinical Studies on the Supplementation of Manufactured Human Milk Oligosaccharides: A Systematic Review.Nutrients · 2023Pooled it
- Trial
- Biosynthesis of human milk oligosaccharides (HMOs) in glycoengineered human cells.Glycobiology · 2026Article
- Multienzyme Platform for the Synthesis of UDP Sugars and Human Milk Oligosaccharides.Chembiochem : a European journal of chemical biology · 2026Article
- Human milk oligosaccharide supplementation for metabolic health and obesity: potential mechanisms, current evidence, and research priorities.World journal of pediatrics : WJP · 2026Article
- Human milk oligosaccharide composition, concentrations and association with maternal factors in the multi-ethnic Asian GUSTO cohort.Frontiers in nutrition · 2026Article
- p-nitrobenzyloxycarbonyl protective group as key to automated glycan assembly of neutral human milk oligosaccharides.Nature communications · 2025Article
- Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review.World journal of clinical pediatrics · 2025Article
- Clinical evidence and mechanistic pathways of human milk oligosaccharide supplementation for health benefits: an updated review.Frontiers in nutrition · 2025Review
- Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing.Frontiers in molecular biosciences · 2025Review
- Identification of nine mammal monosaccharides by solid-state nanopores.Scientific reports · 2024Article
- Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition.Nutrients · 2024Review
- Automated chemoenzymatic modular synthesis of human milk oligosaccharides on a digital microfluidic platform.RSC advances · 2024Article
- Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024Review
- Construction of an engineeredSynthetic and systems biotechnology · 2024Article
- Prebiotics in New-Born and Children's Health.Microorganisms · 2023Review
- Utilizing theInternational journal of molecular sciences · 2023Article
- Infant formulas with synthetic oligosaccharides and respective marketing practices.Molecular and cellular pediatrics · 2022Article
- Engineered Bacillus subtilis for the de novo production of 2'-fucosyllactose.Microbial cell factories · 2022Article
- Fructooligosaccharides are not the same as Fucosylated Human Milk Oligosaccharides.Advances in nutrition (Bethesda, Md.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Lars BodeL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany. lbode@ucsd.edu.
Nikhat ContractorL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Daniela BarileL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Nicola PohlL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Anthony R PruddenL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Geert-Jan BoonsL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Yong-Su JinL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
Stefan JenneweinL. Bode is with the Department of Pediatrics, Mother Milk Infant Center of Research Excellence (MoMI CoRE), University of California, San Diego, La Jolla, California, USA. N. Contractor is with Metagenics, Inc, Gig Harbor, Washington, USA. D. Barile is with the Department of Food Science and Technology, University of California, Davis, Davis, California, USA. N. Pohl is with the Department of Chemistry, Indiana University, Bloomington, Indiana, USA. A.R. Prudden and G.-J. Boons are with the Department of Chemistry and the Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA. Y.-S. Jin is with the Department of Food Science and Human Nutrition, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. S. Jennewein is with Jennewein Biotechnologie GmbH, Rheinbreitbach, Rhineland Palatinate, Germany.
University of Georgia · US
Funding
Sugar Building Blocks and Automated Synthesis of Biomedically-Relevant GlycansU01GM116248 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI POHL, NICOLA L. B. · 2015 to 2019
$2.7MNIGMS NIH HHS U01 GM116248
Abstract
Human milk oligosaccharides (HMOs) are complex sugars highly abundant in human milk but currently not present in infant formula. Rapidly accumulating evidence from in vitro and in vivo studies, combined with epidemiological associations and correlations, suggests that HMOs benefit infants through multiple mechanisms and in a variety of clinical contexts. Until recently, however, research on HMOs has been limited by an insufficient availability of HMOs. Most HMOs are found uniquely in human milk, and thus far it has been prohibitively tedious and expensive to isolate and synthesize them. This article reviews new strategies to overcome this lack of availability by generating HMOs through chemoenzymatic synthesis, microbial metabolic engineering, and isolation from human donor milk or dairy streams. Each approach has its advantages and comes with its own challenges, but combining the different methods and acknowledging their limitations creates new opportunities for research and application with the goal of improving maternal and infant health.
Indexed as
AnimalsBacteriaBiomedical ResearchGenetic EngineeringHumansInfantInfant FormulaInfant, NewbornInfant Nutritional Physiological PhenomenaMilk, HumanNutritive ValueOligosaccharidesOligosaccharidesbioengineeringcarbohydrateshuman milk oligosaccharidesmilkpediatricssynthesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.