Evidence map›Paper›PMID 27634962›Full record

ArticleJournal of neuropathology and experimental neurology2016

Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study.

Robin L Haynes, Rebecca D Folkerth, David S Paterson, Kevin G Broadbelt, S Dan Zaharie, Richard H Hewlett, Johan J Dempers, Elsie Burger, Shabbir Wadee, Pawel Schubert and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Robin L HaynesFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Rebecca D FolkerthFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
David S PatersonFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Kevin G BroadbeltFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
S Dan ZaharieFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Richard H HewlettFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Johan J DempersFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Elsie BurgerFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Shabbir WadeeFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Pawel SchubertFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Colleen WrightFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Mary Ann SensFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Laura NelsenFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Bradley B RandallFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Hoa TranFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Elaine GeldenhuysFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Amy J ElliottFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Hein J OdendaalFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
Hannah C KinneyFrom the Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (RLH, RDF, DSP, KGB, HT, HCK); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (RDF); Department of Pathology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa ((SDZ, RHH, PS, EG); Division of Forensic Pathology and Medicine, Department of Pathology and Western Cape Forensic Pathology Services, Health Science Faculty, Stellenbosch University, Cape Town, South Africa (JJD, EB, SW); National Health Laboratory Services, Port Elizabeth, Eastern Cape, South Africa (CW); Department of Pathology, University of North Dakota, Grand Forks, North Dakota (MAS); Department of Pathology, University of South Dakota School of Medicine, Sioux Falls, South Dakota (LN, BBR); Community and Population Health Sciences, Sanford Research, Sioux Falls, South Dakota (AJE); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Western Cape, South Africa (HJO); The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network (PN).
PASS Network
Brigham and Women's Hospital · USNational Health Laboratory Service · ZABoston Children's Hospital · USHarvard University · USUniversity of North Dakota · USSanford Research · USStellenbosch University · ZAUniversity of South Dakota · US

Funding

VENTRAL MEDULLA, BREATHING, AND CENTRAL CHEMORECEPTIONP01HD036379 · NICHD · HARVARD MEDICAL SCHOOL · PI KINNEY, HANNAH CHASE · 1998 to 2017
$32.2M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD045935 · NICHD · UNIVERSITY OF SOUTH DAKOTA · PI ELLIOTT, AMY J · 2003 to 2015
$16.9M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01AA016501 · NIAAA · STELLENBOSCH UNIVERSITY · PI ODENDAAL, HENDRIK JOHANNES · 2006 to 2015
$10.0M
Safe PASSage Study Administrative Supplement - Effects of Overnight Maternal SleeU01HD055154 · NICHD · DM-STAT, INC. · PI DUKES, KIMBERLY A. · 2006 to 2017
$9.7M
Prenatal Alcohol Sudden Infant Death Syndrome/StillbirthU01HD045991 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KINNEY, HANNAH CHASE · 2003 to 2015
$8.4M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD055155 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIFER, WILLIAM P., MYERS, MICHAEL MORGAN · 2006 to 2015
$7.1M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI KUNKEL, LOUIS M · 2016 to 2020
$5.2M
NIAAA NIH HHS U01 AA016501NICHD NIH HHS P01 HD036379NICHD NIH HHS U01 HD045935NICHD NIH HHS U01 HD045991NICHD NIH HHS U01 HD055154NICHD NIH HHS U01 HD055155NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

The Safe Passage Study is an international, prospective study of approximately 12 000 pregnancies to determine the effects of prenatal alcohol exposure (PAE) upon stillbirth and the sudden infant death syndrome (SIDS). A key objective of the study is to elucidate adverse effects of PAE upon binding to serotonin (5-HT) 1A receptors in brainstem homeostatic networks postulated to be abnormal in unexplained stillbirth and/or SIDS. We undertook a feasibility assessment of 5-HT1A receptor binding using autoradiography in the medulla oblongata (6 nuclei in 27 cases). 5-HT1A binding was compared to a reference dataset from the San Diego medical examiner's system. There was no adverse effect of postmortem interval ≤100 h. The distribution and quantitated values of 5-HT1A binding in Safe Passage Study cases were essentially identical to those in the reference dataset, and virtually identical between stillbirths and live born fetal cases in grossly non-macerated tissues. The pattern of binding was present at mid-gestation with dramatic changes in binding levels in the medullary 5-HT nuclei over the second half of gestation; there was a plateau at lower levels in the neonatal period and into infancy. This study demonstrates feasibility of 5-HT1A binding analysis in the medulla in the Safe Passage Study.

Indexed as

AutoradiographyBrodmann areasPrenatal alcohol exposureSerotonin 1A receptorStillbirthSudden infant death syndrome (SIDS).

Identifiers

PMID27634962
PMCPMC5070458
OpenAlexW2520358976

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