ArticleOncotarget2016
A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.Molecular cancer research : MCR · 2019Article
- Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies.Nature reviews. Urology · 2019Review
- Optimization of Immunofluorescent Detection of Bone Marrow Disseminated Tumor Cells.Biological procedures online · 2018Article
- A surface tension magnetophoretic device for rare cell isolation and characterization.Medical oncology (Northwood, London, England) · 2017Article
- Detection of circulating tumour cells in patients with epithelial ovarian cancer by a microfluidic system.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Bone metastasis is a lethal and incurable disease. It is the result of the dissemination of cancer cells to the bone marrow. Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. Because mouse models represent a crucial tool with which to study cancer metastasis, we developed a novel method for the simple selection-free detection and quantification of bone marrow DTCs in mice. We have used this protocol to detect human and murine DTCs in xenograft, syngeneic, and genetically engineered mouse models. We are able to detect and quantify bone marrow DTCs in mice that do not have overt bone metastasis. This protocol is amenable not only for detection and quantification purposes but also to study the expression of markers of numerous biological processes or tissue-specificity.
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Registered trials
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