Evidence map›Paper›PMID 27634830›Full record

ArticleThe international journal of neuropsychopharmacology2016

Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence.

Kyoji Okita, Mark A Mandelkern, Edythe D London

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  12. The Impact of Combinations of Alcohol, Nicotine, and Cannabis on Dynamic Brain Connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  13. Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kyoji OkitaDepartment of Psychiatry and Biobehavioral Sciences (Drs Okita and London), Department of Molecular and Medical Pharmacology (Dr London), and Brain Research Institute (Dr London), University of California, Los Angeles, CA.
Mark A MandelkernDepartment of Psychiatry and Biobehavioral Sciences (Drs Okita and London), Department of Molecular and Medical Pharmacology (Dr London), and Brain Research Institute (Dr London), University of California, Los Angeles, CA.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences (Drs Okita and London), Department of Molecular and Medical Pharmacology (Dr London), and Brain Research Institute (Dr London), University of California, Los Angeles, CA; elondon@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NEUROCHEMISTRY OF MODAFINIL-MA INTERACTION IN RAT BRAINP20DA022539 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2006 to 2009
$2.9M
Neural Systems, Inhibitory Control, and Methamphetamine DependenceR01DA020726 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2005 to 2008
$2.0M
Early Methamphetamine Abstinence: fMRI and CognitionR01DA015179 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE D · 2003 to 2005
$1.4M
NCRR NIH HHS M01 RR000865NIDA NIH HHS P20 DA022539NIDA NIH HHS R01 DA015179NIDA NIH HHS R01 DA020726NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

backgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 receptor availability in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 receptor availability with smoking exposure and nicotine dependence, therefore, might be expected but have not been tested.

methodsTwenty smokers had positron emission tomography scans with [

resultsAs reported before, lifetime smoking was correlated with nicotine dependence. New findings were that ventral striatal dopamine D2/3 receptor availability was negatively correlated with recent and lifetime smoking and also with nicotine dependence.

conclusionThe results suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence.

Indexed as

SmokersAdolescentAdultBasal GangliaBenzamidesCigarette SmokingContrast MediaCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMolecular ImagingPositron-Emission TomographyPyrrolidinesBenzamidesContrast MediaDRD2 protein, humanDRD3 protein, humanN-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamidePyrrolidinesReceptors, Dopamine D2Receptors, Dopamine D3D2 receptorsdopaminenicotine dependencepositron emission tomography

Identifiers

PMID27634830
PMCPMC5137283
OpenAlexW2519386291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.