Evidence map›Paper›PMID 27634200›Full record

ArticleHaematologica2017

Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice.

Junping Xin, Peter Breslin, Wei Wei, Jing Li, Rafael Gutierrez, Joseph Cannova, Allen Ni, Grace Ng, Rachel Schmidt, Haiyan Chen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  8. RIPK3 signaling and its role in the pathogenesis of cancers.Cellular and molecular life sciences : CMLS · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Junping XinOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA neuroimmune@gmail.com jzhang@luc.edu.
Peter BreslinOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Wei WeiOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Jing LiDepartment of Biology, College of Life and Environment Science, Shanghai Normal University, P.R. of China.
Rafael GutierrezOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Joseph CannovaOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Allen NiOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Grace NgOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Rachel SchmidtOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Haiyan ChenDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Vamsi PariniDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Paul C KuoOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Ameet R KiniDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Patrick StiffOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA.
Jiang ZhuState Key Laboratory for Medical Genomics and Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital; Shanghai Jiao-Tong University School of Medicine, P.R. of China.
Jiwang ZhangOncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA neuroimmune@gmail.com jzhang@luc.edu.
Loyola University Medical Center · USLoyola University Chicago · USShanghai Institute of Hematology · CNShanghai Normal University · CN

Funding

The role of PTEN phosphorylation remodeling in hematopoietic stem cell regulationR01HL095896 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZHANG, JIWANG · 2010 to 2014
$1.8M
Sensitize leukemia cells to differentiation by inhibiting necroptosis signalR21CA181970 · NCI · LOYOLA UNIVERSITY CHICAGO · PI ZHANG, JIWANG · 2014 to 2015
$361k
NCI NIH HHS R21 CA181970NHLBI NIH HHS R01 HL095896
6 · The paper itself

Abstract

Acquired aplastic anemia is an autoimmune-mediated bone marrow failure syndrome. The mechanism by which such an autoimmune reaction is initiated is unknown. Whether and how the genetic lesions detected in patients cause autoimmune bone marrow failure have not yet been determined. We found that mice with spontaneous deletion of the TGFβ-activated kinase-1 gene in a small subset of hematopoietic cells developed bone marrow failure which resembled the clinical manifestations of acquired aplastic anemia patients. Bone marrow failure in such mice could be reversed by depletion of CD4

Indexed as

ApoptosisAutoimmunityMutationNecrosisAnemia, AplasticAnimalsBiomarkersBone MarrowBone Marrow CellsDisease Models, AnimalDisease ProgressionFemaleHematopoiesisHematopoietic Stem CellsInterferon-gammaLymphocyte ActivationBiomarkersInterferon-gammaMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID27634200
PMCPMC5286937
OpenAlexW2519770732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.