Trial reportScientific reports2016
Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Repeated hypergravity training facilitates vestibular compensation associated with dorsal root ganglion remodeling.The journal of physiological sciences : JPS · 2026Article
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- Physiological Changes in the Cardiovascular System During Space Flight - Current Countermeasures and Future Vision.Circulation reports · 2025Review
- Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research.Oncology research · 2025Review
- Review
- Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?Life (Basel, Switzerland) · 2023Review
- Vestibular syncope: clinical characteristics and mechanism.Annals of clinical and translational neurology · 2022Article
- Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro-oncology.Journal of neuroscience research · 2022Review
- Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Exposure to Random Positioning Machine Alters the Mineralization Process and PTX3 Expression in the SAOS-2 Cell Line.Life (Basel, Switzerland) · 2022Article
- Article
- Mechanism for enhancing the growth of mung bean seedlings under simulated microgravity.NPJ microgravity · 2021Article
- Vestibular Illusions and Alterations in Aerospace Environment.Turkish archives of otorhinolaryngology · 2021Review
- Gravitational Influence on Human Living Systems and the Evolution of Species on Earth.Molecules (Basel, Switzerland) · 2021Review
- Gravitational Experimental Platform for Animal Models, a New Platform at ESA's Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models.International journal of molecular sciences · 2021Review
- Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment.The journal of physiological sciences : JPS · 2020Review
- Effect of miR-27b-5p on apoptosis of human vascular endothelial cells induced by simulated microgravity.Apoptosis : an international journal on programmed cell death · 2020Article
- Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation.Frontiers in physiology · 2020Review
- Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.PloS one · 2020Article
- Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex.The journal of physiological sciences : JPS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vestibular system is known to have an important role in controlling blood pressure upon posture transition (vestibulo-cardiovascular reflex, VCR). However, under a different gravitational environment, the sensitivity of the vestibular system may be altered. Thus, the VCR may become less sensitive after spaceflight because of orthostatic intolerance potentially induced by long-term exposure to microgravity. To test this hypothesis in humans, we investigated the ability of the VCR to maintain blood pressure upon head-up tilt before and after a 4-6 months stay on the International Space Station. To detect the functional state of the VCR, galvanic vestibular stimulation (GVS) was applied. As GVS transiently interrupts the vestibular-mediated pressor response, impaired VCR is detected when the head-up tilt-induced blood pressure response does not depend on GVS. During the first 20 s of head-up tilt, a transient blood pressure increase (11.9 ± 1.6 mmHg) was observed at pre-spaceflight but not at 1-4 days after return from spaceflight. The magnitude of VCR recovered to the pre-spaceflight levels within 2 months after return. These results indicate that long-term exposure to microgravity induces VCR impairment, which may be involved in a mechanism of spaceflight-induced orthostatic intolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.