ReviewLearning & memory (Cold Spring Harbor, N.Y.)2016
The potential of epigenetics in stress-enhanced fear learning models of PTSD.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Stress-Enhanced Fear Learning in Rodents: A Systematic Review and Meta-Analysis of Fear-Learning Sensitization After Severe Stress.Brain sciences · 2026Review
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation.Psychopharmacology · 2024Article
- Adolescent Stress Confers Resilience to Traumatic Stress Later in Life: Role of the Prefrontal Cortex.Biological psychiatry global open science · 2023Article
- The Wistar Kyoto Rat: A Model of Depression Traits.Current neuropharmacology · 2023Article
- Epigenetic Approach to PTSD: In the Aspects of Rat Models.Global medical genetics · 2022Review
- How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders.Biological psychiatry · 2021Review
- Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review.Brain sciences · 2021Review
- Prefrontal cortex PACAP signaling: organization and role in stress regulation.Stress (Amsterdam, Netherlands) · 2021Article
- Fear response-based prediction for stress susceptibility to PTSD-like phenotypes.Molecular brain · 2020Article
- Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain.Scientific reports · 2020Article
- Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models.Frontiers in behavioral neuroscience · 2019Article
- White matter integrity alterations in post-traumatic stress disorder.Human brain mapping · 2018Article
- Genetic Model to Study the Co-Morbid Phenotypes of Increased Alcohol Intake and Prior Stress-Induced Enhanced Fear Memory.Frontiers in genetics · 2018Article
- Neuroepigenetics of Post-Traumatic Stress Disorder.Progress in molecular biology and translational science · 2018Review
- Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice.Biological psychiatry · 2017Article
- Persistent effects of acute stress on fear and drug-seeking in a novel model of the comorbidity between post-traumatic stress disorder and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Prolonged distress and dysregulated memory processes are the core features of post-traumatic stress disorder (PTSD) and represent the debilitating, persistent nature of the illness. However, the neurobiological mechanisms underlying the expression of these symptoms are challenging to study in human patients. Stress-enhanced fear learning (SEFL) paradigms, which encompass both stress and memory components in rodents, are emerging as valuable preclinical models of PTSD. Rodent models designed to study the long-term mechanisms of either stress or fear memory alone have identified a critical role for numerous epigenetic modifications to DNA and histone proteins. However, the epigenetic modifications underlying SEFL remain largely unknown. This review will provide a brief overview of the epigenetic modifications implicated in stress and fear memory independently, followed by a description of existing SEFL models and the few epigenetic mechanisms found to date to underlie SEFL. The results of the animal studies discussed here highlight neuroepigenetics as an essential area for future research in the context of PTSD through SEFL studies, because of its potential to identify novel candidates for neurotherapeutics targeting stress-induced pathogenic memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.