ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016
Characterization and mechanisms of the pharyngeal swallow activated by stimulation of the esophagus.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Elicitation of the Swallowing Reflex by Esophageal Stimulation in Healthy Subjects: An Evaluation Using High-Resolution Manometry.Dysphagia · 2020Trial
- The pharyngeal phase of swallowing controls deglutitive inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Coordination of Pharyngeal and Esophageal Phases of Swallowing.Journal of neurogastroenterology and motility · 2024Review
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Biomechanical increase in cervical esophageal wall tension during peristalsis.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Serotonin therapies for opioid-induced disordered swallow and respiratory depression.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Biomechanical effects of esophageal elongation on the circumferential tension of the cervical esophagus in vivo.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- A biomechanical response of the esophagus participates in swallowing.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Article
- Vagus Nerves Provide a Robust Afferent Innervation of the Mucosa Throughout the Body of the Esophagus in the Mouse.Dysphagia · 2020Article
- Pharyngoesophageal and cardiorespiratory interactions: potential implications for premature infants at risk of clinically significant cardiorespiratory events.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Pathological classification of equine recurrent laryngeal neuropathy.Journal of veterinary internal medicine · 2018Review
- The effect of body position on esophageal reflexes in cats: a possible mechanism of SIDS?Pediatric research · 2018Article
- Characterization and mechanisms of the supragastric belch in the cat.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Stimulation of the esophagus activates the pharyngeal swallow response (EPSR) in human infants and animals. The aims of this study were to characterize the stimulus and response of the EPSR and to determine the function and mechanisms generating the EPSR. Studies were conducted in 46 decerebrate cats in which pharyngeal, laryngeal, and esophageal motility was monitored using EMG, strain gauges, or manometry. The esophagus was stimulated by balloon distension or luminal fluid infusion. We found that esophageal distension increased the chance of occurrence of the EPSR, but the delay was variable. The chance of occurrence of the EPSR was related to the position, magnitude, and length of the stimulus in the esophagus. The most effective stimulus was long, strong, and situated in the cervical esophagus. Acidification of the esophagus activated pharyngeal swallows and sensitized the receptors that activate the EPSR. The EPSR was blocked by local anesthesia applied to the esophageal lumen, and electrical stimulation of the recurrent laryngeal nerve caudal to the cricoid cartilage (RLNc) activated the pharyngeal swallow response. We conclude that the EPSR is activated in a probabilistic manner. The receptors mediating the EPSR are probably mucosal slowly adapting tension receptors. The sensory neural pathway includes the RLNc and superior laryngeal nerve. We hypothesize that, because the EPSR is observed in human infants and animals, but not human adults, activation of EPSR is related to the elevated position of the larynx. In this situation, the EPSR occurs rather than secondary peristalsis to prevent supraesophageal reflux when the esophageal bolus is in the proximal esophagus.
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