ArticleScientific reports2016
A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Characterization of the urinary DNA virome of hematopoietic stem cell transplant recipient and healthy cynomolgus macaques.bioRxiv : the preprint server for biology · 2026Article
- Deciphering the cancer chemopreventive potential of phytochemicals: an integrative perspective on molecular targets and signaling networks.Cancer cell international · 2026Review
- Rapid and accurate testing for urinary tract infection: new clothes for the emperor.Clinical microbiology reviews · 2025Review
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Metagenomic analysis reveals the diversity of the vaginal virome and its association with vaginitis.Frontiers in cellular and infection microbiology · 2025Article
- The role of the DE and EF loop of BKPyV VP1 in the serological cross-reactivity between subtypes.Virus research · 2023Article
- Urine microbiome in individuals with an impaired immune system.Frontiers in cellular and infection microbiology · 2023Review
- The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.Frontiers in immunology · 2022Review
- Urinary Tract Virome as an Urgent Target for Metagenomics.Life (Basel, Switzerland) · 2021Review
- Article
- Detection of Quebec Polyomavirus DNA in Samples from Different Patient Groups.Microorganisms · 2021Article
- Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients.Clinical microbiology reviews · 2020Review
- Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.PLoS pathogens · 2020Article
- Impact of the microbiota on solid organ transplant rejection.Current opinion in organ transplantation · 2019Review
- Urobiome: In Sickness and in Health.Microorganisms · 2019Review
- High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach.The Journal of infectious diseases · 2019Article
- Metagenomic Virome Sequencing in Living Donor and Recipient Kidney Transplant Pairs Revealed JC Polyomavirus Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Bacteriophages of the lower urinary tract.Nature reviews. Urology · 2019Review
- The Bladder is Not Sterile: an Update on the Urinary Microbiome.Current bladder dysfunction reports · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have established that the human urine contains a complex microbiome, including a virome about which little is known. Following immunosuppression in kidney transplant patients, BK polyomavirus (BKV) has been shown to induce nephropathy (BKVN), decreasing graft survival. In this study we investigated the urine virome profile of BKV+ and BKV- kidney transplant recipients. Virus-like particles were stained to confirm the presence of VLP in the urine samples. Metagenomic DNA was purified, and the virome profile was analyzed using metagenomic shotgun sequencing. While the BK virus was predominant in the BKV+ group, it was also found in the BKV- group patients. Additional viruses were also detected in all patients, notably including JC virus (JCV) and Torque teno virus (TTV) and interestingly, we detected multiple subtypes of the BKV, JCV and TTV. Analysis of the BKV subtypes showed that nucleotide polymorphisms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functional effects for enhanced pathogenicity. Our results demonstrate a complex urinary virome in kidney transplant patients with multiple viruses with several distinct subtypes warranting further analysis of virus subtypes in immunosuppressed hosts.
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