ArticleScientific reports2016
Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.Brain and behavior · 2025Pooled it
- Neurodevelopmental outcomes of infants born at high altitude: evidence from Tibet.Pediatric research · 2026Article
- Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study.Scientific reports · 2026Article
- Reversible brain functional alterations induced by Short-Term high altitude exposure.Brain imaging and behavior · 2026Article
- Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- Investigating Sea-Level Brain Predictors for Acute Mountain Sickness: A Multimodal MRI Study before and after High-Altitude Exposure.AJNR. American journal of neuroradiology · 2024Article
- Hypoxic White Matter Injury and Recovery After Reoxygenation in Adult Mice: Magnetic Resonance Imaging Findings and Histological Studies.Cellular and molecular neurobiology · 2023Article
- The Brain at High Altitude: From Molecular Signaling to Cognitive Performance.International journal of molecular sciences · 2023Review
- Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.Brain imaging and behavior · 2023Article
- Resting-State Neuronal Activity and Functional Connectivity Changes in the Visual Cortex after High Altitude Exposure: A Longitudinal Study.Brain sciences · 2022Article
- The human brain in a high altitude natural environment: A review.Frontiers in human neuroscience · 2022Review
- Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.Physiological reports · 2021Article
- Effects of weather and season on human brain volume.PloS one · 2021Article
- Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents.International journal of molecular sciences · 2020Review
- Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a NovelFrontiers in neurology · 2020Article
- Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.Scientific reports · 2019Article
- Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study.Human brain mapping · 2019Article
- Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain sickness. Whether their brains have indeed suffered from HA environment and the persistent sequelae after return to lowland remain unknown. Thirty-one sea-level college students, who had a 30-day teaching on Qinghai-Tibet plateau underwent MRI scans before, during, and two months after HA exposure. Brain volume, cortical structures, and white matter microstructure were measured. Besides, serum neuron-specific enolase (NSE), C-reactive protein, and interleukin-6 and neuropsychiatric behaviors were tested. After 30-day HA exposure, the gray and white matter volumes and cortical surface areas significantly increased, with cortical thicknesses and curvatures changed in a wide spread regions; Anisotropy decreased with diffusivities increased in multiple sites of white matter tracts. Two months after HA exposure, cortical measurements returned to basal level. However, increased anisotropy with decreased diffusivities was observed. Behaviors and serum inflammatory factor did not significant changed during three time-point tests. NSE significantly decreased during HA but increased after HA exposure. Results suggest brain swelling occurred in people without neurological signs at HA, but no negative sequelae in cortical structures and neuropsychiatric functions were left after the return to lowlands. Reoxygenation changed white matter microstructure.
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