ArticleThe Journal of physiology2016
Central control of interlimb coordination and speed-dependent gait expression in quadrupeds.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 130 citations in OpenAlex.
- Cervical and thoracolumbar transspinal stimulation at 0.3 Hz and 30 Hz facilitates neuronal excitability in healthy humans: a randomized cross-over study.Experimental brain research · 2025Trial
- Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.Neural regeneration research · 2026Article
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Speed-Dependent Turning Strategies in Quadrupedal Locomotion: Insights from Computational Modeling.bioRxiv : the preprint server for biology · 2026Article
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- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- Speed-dependent turning strategies in quadrupedal locomotion: insights from computational modeling.Frontiers in bioengineering and biotechnology · 2026Article
- Recovery in gait and posture: a network-based approach to the assessment of rehabilitation effectiveness after spinal cord injury.Frontiers in network physiology · 2026Article
- Mechanisms of adaptive interlimb coordination to sudden ground loss: a neuromusculoskeletal modeling study.bioRxiv : the preprint server for biology · 2025Article
- Rhythmic categories in horse gait kinematics.Journal of anatomy · 2025Article
- Direct and Retrograde Wave Propagation in Unidirectionally Coupled Wilson-Cowan Oscillators.Physical review letters · 2025Article
- Foot trajectory as a key factor for diverse gait patterns in quadruped robot locomotion.Scientific reports · 2025Article
- Minimization of prediction errors during cerebral embryogenesis and the emergence of agency.Frontiers in systems neuroscience · 2025Article
- Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord.PLoS computational biology · 2025Article
- Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
- Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion.bioRxiv : the preprint server for biology · 2023Article
- Spinal control of locomotion before and after spinal cord injury.Experimental neurology · 2023Article
- Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.Current biology : CB · 2023Article
- Rare phenomena of central rhythm and pattern generation in a case of complete spinal cord injury.Nature communications · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
key pointsQuadrupeds express different gaits depending on speed of locomotion. Central pattern generators (one per limb) within the spinal cord generate locomotor oscillations and control limb movements. Neural interactions between these generators define interlimb coordination and gait. We present a computational model of spinal circuits representing four rhythm generators with left-right excitatory and inhibitory commissural and fore-hind inhibitory interactions within the cord. Increasing brainstem drive to all rhythm generators and excitatory commissural interneurons induces an increasing frequency of locomotor oscillations accompanied by speed-dependent gait changes from walk to trot and to gallop and bound. The model closely reproduces and suggests explanations for multiple experimental data, including speed-dependent gait transitions in intact mice and changes in gait expression in mutants lacking certain types of commissural interneurons. The model suggests the possible circuit organization in the spinal cord and proposes predictions that can be tested experimentally. ABSTRACT: As speed of locomotion is increasing, most quadrupeds, including mice, demonstrate sequential gait transitions from walk to trot and to gallop and bound. The neural mechanisms underlying these transitions are poorly understood. We propose that the speed-dependent expression of different gaits results from speed-dependent changes in the interactions between spinal circuits controlling different limbs and interlimb coordination. As a result, the expression of each gait depends on (1) left-right interactions within the spinal cord mediated by different commissural interneurons (CINs), (2) fore-hind interactions on each side of the spinal cord and (3) brainstem drives to rhythm-generating circuits and CIN pathways. We developed a computational model of spinal circuits consisting of four rhythm generators (RGs) with bilateral left-right interactions mediated by V0 CINs (V0
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.