ArticlePharmaceutical research2016
The Use of a Pressure-Indicating Sensor Film to Provide Feedback upon Hydrogel-Forming Microneedle Array Self-Application In Vivo.
Article in Pharmaceutical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Assessment of leachables and extractables in "super-swelling" hydrogel-forming microarray patches.Drug delivery and translational research · 2026Article
- Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics.Gels (Basel, Switzerland) · 2025Review
- The Relationship between Immunogenicity and Reactogenicity of Seasonal Influenza Vaccine Using Different Delivery Methods.Vaccines · 2024Article
- Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture-Indicating Silica.Advanced healthcare materials · 2024Article
- Swellable Microneedles in Drug Delivery and Diagnostics.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Progress in Intradermal and Transdermal Gene Therapy with Microneedles.Pharmaceutical research · 2022Review
- Advances in microneedle-based transdermal delivery for drugs and peptides.Drug delivery and translational research · 2022Review
- Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept study.Drug delivery and translational research · 2022Article
- Enhancement strategies for transdermal drug delivery systems: current trends and applications.Drug delivery and translational research · 2022Article
- Bioimaging of Dissolvable Microneedle Arrays: Challenges and Opportunities.Research (Washington, D.C.) · 2022Review
- From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium.Drug delivery and translational research · 2021Article
- Microarray patches enable the development of skin-targeted vaccines against COVID-19.Advanced drug delivery reviews · 2021Review
- Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion.Nano-micro letters · 2021Review
- Safe Coated Microneedles with Reduced Puncture Occurrence after Administration.Micromachines · 2020Article
- Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations.Pharmaceutical research · 2020Review
- Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches.Drug delivery and translational research · 2020Article
- Novel Design Approaches in the Fabrication of Polymeric Microarray Patches via Micromoulding.Micromachines · 2020Article
- A Snapshot of Transdermal and Topical Drug Delivery Research in Canada.Pharmaceutics · 2019Review
- Development of a thermostable microneedle patch for polio vaccination.Drug delivery and translational research · 2019Article
- Technology update: dissolvable microneedle patches for vaccine delivery.Medical devices (Auckland, N.Z.) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the combination of a pressure-indicating sensor film with hydrogel-forming microneedle arrays, as a method of feedback to confirm MN insertion in vivo.
methodsPilot in vitro insertion studies were conducted using a Texture Analyser to insert MN arrays, coupled with a pressure-indicating sensor film, at varying forces into excised neonatal porcine skin. In vivo studies involved twenty human volunteers, who self-applied two hydrogel-forming MN arrays, one with a pressure-indicating sensor film incorporated and one without. Optical coherence tomography was employed to measure the resulting penetration depth and colorimetric analysis to investigate the associated colour change of the pressure-indicating sensor film.
resultsMicroneedle insertion was achieved in vitro at three different forces, demonstrating the colour change of the pressure-indicating sensor film upon application of increasing pressure. When self-applied in vivo, there was no significant difference in the microneedle penetration depth resulting from each type of array, with a mean depth of 237 μm recorded. When the pressure-indicating sensor film was present, a colour change occurred upon each application, providing evidence of insertion.
conclusionsFor the first time, this study shows how the incorporation of a simple, low-cost pressure-indicating sensor film can indicate microneedle insertion in vitro and in vivo, providing visual feedback to assure the user of correct application. Such a strategy may enhance usability of a microneedle device and, hence, assist in the future translation of the technology to widespread clinical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.