ArticlePlant biotechnology journal2017
The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport.
Article in Plant biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 70 citations in OpenAlex.
- Genome-wide identification of the oligopeptide transporter gene family in poplar and their responses to iron and cadmium.BMC plant biology · 2025Article
- Isolation of Bacteria from Lead-Contaminated Soil and Bacterial Interaction Test with Plant Growing on Lead-Amended Media.Tropical life sciences research · 2025Article
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- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- A two-gene strategy increases iron and zinc concentrations in wheat flour, improving mineral bioaccessibility.Plant physiology · 2023Article
- Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase.Rice (New York, N.Y.) · 2022Article
- Genetic Approaches for Iron and Zinc Biofortification and Arsenic Decrease in Oryza sativa L. Grains.Biological trace element research · 2022Review
- A tale of two metals: Biofortification of rice grains with iron and zinc.Frontiers in plant science · 2022Review
- Strategies and Bottlenecks in Hexaploid Wheat to Mobilize Soil Iron to Grains.Frontiers in plant science · 2022Review
- Research and Progress on the Mechanism of Iron Transfer and Accumulation in Rice Grains.Plants (Basel, Switzerland) · 2021Review
- AtfA-Independent Adaptation to the Toxic Heavy Metal Cadmium inMicroorganisms · 2021Article
- Review
- Improving nutritional quality of rice for human health.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- High-frequency random DNA insertions upon co-delivery of CRISPR-Cas9 ribonucleoprotein and selectable marker plasmid in rice.Scientific reports · 2019Article
- The ratio of phytosiderophores nicotianamine to deoxymugenic acid controls metal homeostasis in rice.Planta · 2019Article
- Iron Biofortification of Staple Crops: Lessons and Challenges in Plant Genetics.Plant & cell physiology · 2019Review
- Tolerance of Iron-Deficient and -Toxic Soil Conditions in Rice.Plants (Basel, Switzerland) · 2019Review
- Genetic Biofortification to Enrich Rice and Wheat Grain Iron: From Genes to Product.Frontiers in plant science · 2019Review
- Genome-wide analysis of oligopeptide transporters and detailed characterization of yellow stripe transporter genes in hexaploid wheat.Functional & integrative genomics · 2019Article
- Analysis of Yellow Striped Mutants ofFrontiers in plant science · 2018Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many metal transporters in plants are promiscuous, accommodating multiple divalent cations including some which are toxic to humans. Previous attempts to increase the iron (Fe) and zinc (Zn) content of rice endosperm by overexpressing different metal transporters have therefore led unintentionally to the accumulation of copper (Cu), manganese (Mn) and cadmium (Cd). Unlike other metal transporters, barley Yellow Stripe 1 (HvYS1) is specific for Fe. We investigated the mechanistic basis of this preference by constitutively expressing HvYS1 in rice under the control of the maize ubiquitin1 promoter and comparing the mobilization and loading of different metals. Plants expressing HvYS1 showed modest increases in Fe uptake, root-to-shoot translocation, seed accumulation and endosperm loading, but without any change in the uptake and root-to-shoot translocation of Zn, Mn or Cu, confirming the selective transport of Fe. The concentrations of Zn and Mn in the endosperm did not differ significantly between the wild-type and HvYS1 lines, but the transgenic endosperm contained significantly lower concentrations of Cu. Furthermore, the transgenic lines showed a significantly reduced Cd uptake, root-to-shoot translocation and accumulation in the seeds. The underlying mechanism of metal uptake and translocation reflects the down-regulation of promiscuous endogenous metal transporters revealing an internal feedback mechanism that limits seed loading with Fe. This promotes the preferential mobilization and loading of Fe, therefore displacing Cu and Cd in the seed.
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