Evidence map›Paper›PMID 27633419›Full record

ArticleJournal of surgical oncology2016

Actual 10-year survivors following resection of adrenocortical carcinoma.

Thuy B Tran, Lauren M Postlewait, Shishir K Maithel, Jason D Prescott, Tracy S Wang, Jason Glenn, John E Phay, Kara Keplinger, Ryan C Fields, Linda X Jin and 17 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 1 country.

Thuy B TranDepartment of Surgery, Stanford University School of Medicine, Stanford, California.
Lauren M PostlewaitDepartment of Surgery, Emory University, Atlanta, Georgia.
Shishir K MaithelDepartment of Surgery, Emory University, Atlanta, Georgia.
Jason D PrescottDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Tracy S WangDepartment of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jason GlennDepartment of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
John E PhayDepartment of Surgery, Ohio State University, Columbus, Ohio.
Kara KeplingerDepartment of Surgery, Ohio State University, Columbus, Ohio.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Linda X JinDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Sharon M WeberDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ahmed SalemDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Jason K SicklickDepartment of Surgery, University of California San Diego, San Diego, California.
Shady GadDepartment of Surgery, University of California San Diego, San Diego, California.
Adam C YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
John C MansourDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
Quan-Yang DuhDepartment of Surgery, University of California San Francisco, San Francisco, California.
Natalie SeiserDepartment of Surgery, University of California San Francisco, San Francisco, California.
Carmen C SolorzanoDepartment of Surgery, Vanderbilt University, Nashville, Tennessee.
Colleen M KiernanDepartment of Surgery, Vanderbilt University, Nashville, Tennessee.
Konstantinos I VotanopoulosDepartment of Surgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina.
Edward A LevineDepartment of Surgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina.
Ioannis HatzarasDepartment of Surgery, New York University School of Medicine, New York, New York.
Rivfka ShenoyDepartment of Surgery, New York University School of Medicine, New York, New York.
Timothy M PawlikDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jeffrey A NortonDepartment of Surgery, Stanford University School of Medicine, Stanford, California.
George A PoultsidesDepartment of Surgery, Stanford University School of Medicine, Stanford, California.
Stanford University · USAtrium Health Wake Forest Baptist · USEmory University · USMedical College of Wisconsin · USNew York University · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Diego · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USVanderbilt University · USWashington University in St. Louis · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor SyndromeR21CA192072 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2016 to 2017
$399k
NCI NIH HHS K08 CA168999NCI NIH HHS R21 CA192072
6 · The paper itself

Abstract

backgroundAdrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options beyond surgical resection. The characteristics of actual long-term survivors following surgical resection for ACC have not been previously reported.

methodPatients who underwent resection for ACC at one of 13 academic institutions participating in the US Adrenocortical Carcinoma Group from 1993 to 2014 were analyzed. Patients were stratified into four groups: early mortality (died within 2 years), late mortality (died within 2-5 years), actual 5-year survivor (survived at least 5 years), and actual 10-year survivor (survived at least 10 years). Patients with less than 5 years of follow-up were excluded.

resultsAmong the 180 patients available for analysis, there were 49 actual 5-year survivors (27%) and 12 actual 10-year survivors (7%). Patients who experienced early mortality had higher rates of cortisol-secreting tumors, nodal metastasis, synchronous distant metastasis, and R1 or R2 resections (all P < 0.05). The need for multi-visceral resection, perioperative blood transfusion, and adjuvant therapy correlated with early mortality. However, nodal involvement, distant metastasis, and R1 resection did not preclude patients from becoming actual 10-year survivors. Ten of twelve actual 10-year survivors were women, and of the seven 10-year survivors who experienced disease recurrence, five had undergone repeat surgery to resect the recurrence.

conclusionSurgery for ACC can offer a 1 in 4 chance of actual 5-year survival and a 1 in 15 chance of actual 10-year survival. Long-term survival was often achieved with repeat resection for local or distant recurrence, further underscoring the important role of surgery in managing patients with ACC. J. Surg. Oncol. 2016;114:971-976. © 2016 Wiley Periodicals, Inc.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaAdultAgedDatabases, FactualFemaleFollow-Up StudiesHumansMaleMiddle AgedSurvival AnalysisTreatment OutcomeUnited Statesadrenal canceradrenocortical carcinomasurgerysurvival

Identifiers

PMID27633419
PMCPMC5278771
OpenAlexW2522598788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.