Evidence map›Paper›PMID 27633073›Full record

ReviewCurrent cardiology reviews2017

Considerations in Understanding the Coronary Blood Flow- Left Ventricular Mass Relationship in Patients with Hypertension.

Simon W Rabkin

Open access · greenAbstract readReview
In one paragraph

Review in Current cardiology reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  4. Review
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  7. Role of nuclear cardiology in diagnosis and risk stratification of coronary microvascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Simon W RabkinUniversity of British Columbia, Level 9 - 2775 Laurel St, Vancouver, B.C., Canada V5Z 1M9.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary blood flow (CBF) is essential for optimal cardiac performance and to maintain myocardial viability. There is considerable ambiguity concerning CBF in hypertension.

objectiveTo investigate the relationship between CBF and left ventricular (LV) mass in persons with hypertension.

methodsOvidSP Medline was systematically searched. Eligible articles assessed CBF, and LV mass in adults with and without hypertension (HTN).

resultsEleven studies met the entry criteria. All 8 studies reported an increase in CBF (ml/min) for persons with hypertension (N=212) compared to individuals without hypertension (N=150). Metaanalysis showed a significant and 2.88 fold higher CBP in hypertension. Six studies adjusted CBF for LV mass; of which 4 studies reported a reduction in CBF. Meta-analysis showed a significant decrease in CBF/g LV mass in hypertension. The two studies that did not show a decrease in CBF, used the argon chromatographic method to measure coronary sinus blood flow suggesting this methodology may have influenced the results. Using the mean CBF in normotensive group to construct the expected CBF according to LV mass, reported CBF in HTN was progressively less than expected In two studies, (N=142), there was a significant inverse correlation between LV mass and CBF/ g LV mass. Multivariate analysis (three studies) consistently found a highly significant independent relationship between LV mass and CBF after considering age, sex, heart rate and several other factors.

conclusionHypertension is associated with a reduction in CBF adjusted for LV mass with a highly significant inverse association between CBF and LV mass. Clinicians should be aware that patients with hypertension are at greater risk for myocardial ischemia should develop other factors that limit CBF or myocardial oxygen delivery.

Indexed as

Coronary CirculationFemaleHeart RateHumansHypertensionHypertrophy, Left VentricularMale

Identifiers

PMID27633073
PMCPMC5324321
OpenAlexW2521514735

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.