Evidence map›Paper›PMID 27633032›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2016

Composition of gallbladder bile in healthy individuals and patients with gallstone disease from north and South India.

V Jayanthi, S Sarika, Joy Varghese, V Vaithiswaran, Malay Sharma, Mettu Srinivas Reddy, Vijaya Srinivasan, G M M Reddy, Mohamed Rela, S Kalkura

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03981315 (Gallbladder Bile Composition in Patients With Gallstones and Healthy Patients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03981315 unknown statusnot on this mapstarted 2019, after this paper: background citation

Gallbladder Bile Composition in Patients With Gallstones and Healthy Patients

Typeobservational_patient_registrySponsorHospital Son EspasesRan2019 to 2022Enrolled62ConditionsCholelithiasis, Gall Stone, Gall Bladder DiseaseArmsBile test, Blood test, Gall stone study, Microbiological bile test
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Microstructural diversity of gallstones revealed by spectral microanalyses and their association with hepatic parameters.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

V JayanthiGastroenterology and Hepatology, Institute of Gastrosciences, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India. drjayanthi35@yahoo.co.in.
S SarikaCrystal Growth Center, AC Technology, University of Madras, Chepauk, Chennai, 600 005, India.
Joy VargheseInstitute of Liver Disease and Liver Transplant, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.
V VaithiswaranGastroenterology and Hepatology, Institute of Gastrosciences, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.
Malay SharmaJaswant Rai Specialty Hospital, Mawana Road, Meerut, 250 001, India.
Mettu Srinivas ReddyInstitute of Liver Disease and Liver Transplant, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.
Vijaya SrinivasanGastroenterology and Hepatology, Institute of Gastrosciences, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.
G M M ReddyChettinad Hospital and Research Institute, Rajiv Gandhi Salai, OMR Chennai, Kelambakkam, Chennai, 603 103, India.
Mohamed RelaInstitute of Liver Disease and Liver Transplant, Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.
S KalkuraCrystal Growth Center, AC Technology, University of Madras, Chepauk, Chennai, 600 005, India.
Institute of Liver and Biliary Sciences · INUniversity of Madras · INChettinad Health City · INJaswant Rai Speciality Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGallstones (GS) in south India (SI) are predominantly pure pigment or mixed, while in North India (NI), these are either pure cholesterol or mixed. While cholesterol rich gallbladder (GB) bile predicts cholesterol GS, constituent of bile in primary pigment GS is not known. We compared the composition of GB bile from healthy liver donors and patients with GS from north and south India.

methodsGallbladder bile from healthy liver donors from north (10) and south India (8) served as controls. Cases were patients from north (21) and south India (17) who underwent cholecystectomy for GS disease. Gallbladder bile from both cases and controls was analyzed for cholesterol, lecithin (phospholipid), and bile salts. Gallstones were classified as cholesterol, mixed, and pigment based on morphology and biochemical analysis.

resultsThe median cholesterol concentration in control bile from north was significantly high compared to south (p<0.001) with no difference in lecithin and bile salts (p NS). Except for one sample each from north and south, the cholesterol solubility of controls was within the critical micellar zone. Mixed GS were most frequent in north India (61.9 %) while pigment GS dominated in south (61.9 %). The median cholesterol concentration in bile samples of cholecystectomy patients from north India was significantly high GS (p < 0.00001) with significant lowering of bile salts and lecithin (p < 0.00001). In south India, patients with mixed GS had high cholesterol content in bile compared to controls and patients with pigment GS; bile in latter had significantly higher concentration of bile salt compared to controls and mixed GS. The ternary plot confirmed the composition of GB bile from north and south India.

conclusionsGallbladder bile in controls and patients with GS from north India had significantly high cholesterol concentration. In south India, patients with mixed GS had cholesterol rich bile while pigment GS had higher concentrations of bile salts.

Indexed as

BileBile Acids and SaltsCholesterolGallbladderGallstonesHumansIndiaLecithinsBile Acids and SaltsCholesterolLecithinsBile acidsBile saltsCholesterolGallstone diseaseHealthy gallbladder bileLecithin

Identifiers

PMID27633032
OpenAlexW2519334087

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Registered trials

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