Evidence map›Paper›PMID 27632935›Full record

SynthesisScientific reports2016

THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer.

Xue Wang, Lei Zhang, Hui Li, WenJie Sun, Honghe Zhang, Maode Lai

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 99 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xue WangDepartment of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
Lei ZhangDepartment of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
Hui LiDepartment of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
WenJie SunDepartment of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Honghe ZhangDepartment of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Maode LaiDepartment of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China.
Zhejiang University · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the understanding of the complicated carcinogenesis process was enormously hindered by large-scale tumor heterogeneity. Here we proposed that the prognosis-related gene THBS2, responsible for cooperativity disorientation, probably contain untapped prognostic resource of colorectal cancer. We originally established Spearman correlation transition, Kaplan-Meier survival analysis and meta-analysis that combine public dataset and clinical samples to quantify the prognostic value of THBS2. THBS2 could be considered as a novel prognostic marker in colorectal cancer.

Indexed as

Biomarkers, TumorCell ProliferationCluster AnalysisColorectal NeoplasmsDatabases as TopicFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm MetastasisPrognosisProportional Hazards ModelsReproducibility of ResultsBiomarkers, TumorThrombospondin 2Thrombospondins

Identifiers

PMID27632935
PMCPMC5025892
OpenAlexW2520996698

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.