ArticlePediatric research2017
Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.BMJ (Clinical research ed.) · 2023Pooled it
- The effect of antenatal corticosteroid use on offspring cardiovascular function: A systematic review.BJOG : an international journal of obstetrics and gynaecology · 2023Pooled it
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- Time and frequency domain assessment of heart rate variability in patients with pulmonary sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Heart Rate and Heart Rate Variability in Healthy Preterm-Born Young Adults and Association with Vitamin D: A Wearable Device Assessment.Journal of clinical medicine · 2023Article
- A Reduction in Antenatal Steroid Dose Was Associated with Reduced Cardiac Dysfunction in a Sheep Model of Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The role of antenatal corticosteroids in twin pregnancy.Frontiers in pharmacology · 2023Review
- Cardiac autonomic dysfunction in survivors of childhood acute lymphoblastic leukemia: The St. Jude Lifetime Cohort Study.Pediatric blood & cancer · 2020Article
- Antenatal Steroid Exposure, Aerobic Fitness, and Physical Activity in Adolescents Born Preterm with Very Low Birth Weight.The Journal of pediatrics · 2019Observational
- Central ANG-(1-7) infusion improves blood pressure regulation in antenatal betamethasone-exposed sheep and reveals sex-dependent effects on oxidative stress.American journal of physiology. Heart and circulatory physiology · 2019Article
- Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.Clinical science (London, England : 1979) · 2019Review
- Renal function and blood pressure are altered in adolescents born preterm.Pediatric nephrology (Berlin, Germany) · 2019Observational
- Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure.Clinical science (London, England : 1979) · 2018Article
- Antenatal corticosteroids and cardiometabolic outcomes in adolescents born with very low birth weight.Pediatric research · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundReduced heart rate variability (HRV) suggests autonomic imbalance in the control of heart rate and is associated with unfavorable cardiometabolic outcomes. We examined whether antenatal corticosteroid (ANCS) exposure had long-term programming effects on HRV in adolescents born with very low birth weight (VLBW).
methodsFollow-up study of a cohort of VLBW 14-y olds born between 1992 and 1996 with 50% exposed to ANCS. HRV in both the time and frequency domains using Nevrokard Software was determined from a 5-min electrocardiogram tracing.
resultsHRV data from 89 (35 male, 53 non-black) exposed (ANCS+) and 77 (28 male, 29 non-black) unexposed (ANCS-) adolescents were analyzed. HRV did not differ between ANCS+ and ANCS- black participants. However, in non-black participants, a significant interaction between ANCS and sex was observed, with ANCS- females having significantly greater HRV than ANCS+ females and males, and ANCS- males for both time and frequency domain variables.
conclusionAmong non-black adolescents born with VLBW, ANCS exposure is associated with reduced HRV with apparent sex-specificity. Reduced HRV has been associated with development of adverse cardiometabolic outcomes, thus supporting the need to monitor these outcomes in VLBW adolescents as they mature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.