Evidence map›Paper›PMID 27632689›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2017

My46: a Web-based tool for self-guided management of genomic test results in research and clinical settings.

Holly K Tabor, Seema M Jamal, Joon-Ho Yu, Julia M Crouch, Aditi G Shankar, Karin M Dent, Nick Anderson, Damon A Miller, Brett T Futral, Michael J Bamshad

Abstract read
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
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  11. Review
  12. Informed Consent in the Genomics Era.Cold Spring Harbor perspectives in medicine · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Holly K TaborDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1005-5008
Seema M JamalDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5427-8839
Joon-Ho YuDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9635-8618
Julia M CrouchTreuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-7694-1881
Aditi G ShankarDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3938-5652
Karin M DentDepartment of Pediatrics University of Utah, Salt Lake City, Utah, USA.
Nick AndersonDepartment of Public Health Sciences, University of California, Davis, Sacramento, California, USA.ORCID 0000-0002-2999-7284
Damon A MillerCatalyst IT Services, Beaverton, Oregon, USA.ORCID 0000-0002-8095-5653
Brett T FutralCatalyst IT Services, Beaverton, Oregon, USA.
Michael J BamshadDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.

Funding

UW Center for Mendelian GenomicsU54HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, NICKERSON, DEBORAH A · 2012 to 2015
$20.0M
UW Center for Mendelian GenomicsUM1HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, LEAL, SUZANNE M · 2016 to 2020
$15.3M
Innovative Approaches to Returning Results in Exome and Genome Sequencing StudiesR01HG006618 · NHGRI · SEATTLE CHILDREN'S HOSPITAL · PI TABOR, HOLLY K · 2011 to 2013
$2.2M
Ethical and Social Issues in the Study of Genetics of Complex TraitsR00HG004316 · NHGRI · SEATTLE CHILDREN'S HOSPITAL · PI TABOR, HOLLY K · 2008 to 2010
$722k
Returning Exome and Whole Genome Results To Underserved Minority PopulationsK99HG007076 · NHGRI · UNIVERSITY OF WASHINGTON · PI YU, JOON-HO · 2014 to 2015
$199k
NHGRI NIH HHS K99 HG007076NHGRI NIH HHS R00 HG004316NHGRI NIH HHS R01 HG006618NHGRI NIH HHS U54 HG006493NHGRI NIH HHS UM1 HG006493NICHD NIH HHS HHSN267200700023C
6 · The paper itself

Abstract

A major challenge to implementing precision medicine is the need for an efficient and cost-effective strategy for returning individual genomic test results that is easily scalable and can be incorporated into multiple models of clinical practice. My46 is a Web-based tool for managing the return of genetic results that was designed and developed to support a wide range of approaches to disclosing results, ranging from traditional face-to-face disclosure to self-guided models. My46 has five key functions: set and modify results-return preferences, return results, educate, manage the return of results, and assess the return of results. These key functions are supported by six distinct modules and a suite of features that enhance the user experience, ease site navigation, facilitate knowledge sharing, and enable results-return tracking. My46 is a potentially effective solution for returning results and supports current trends toward shared decision making between patients and providers and patient-driven health management.Genet Med 19 4, 467-475.

Indexed as

Patient Access to RecordsBiomedical ResearchComputational BiologyDecision MakingGenomicsHumansInternetMedical InformaticsPrecision Medicine

Identifiers

PMID27632689
PMCPMC5352554

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.