Evidence map›Paper›PMID 27632386›Full record

SynthesisNeuropsychology review2016

Does Therapeutic Repetitive Transcranial Magnetic Stimulation Cause Cognitive Enhancing Effects in Patients with Neuropsychiatric Conditions? A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Donel M Martin, Shawn M McClintock, Jane Forster, Colleen K Loo

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06152705 (Triple-blind Randomized Trial Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression), which is not on this map. Cited by 33 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 9 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06152705 narecruitingnot on this mapstarted 2024, after this paper: background citation

Triple-blind Randomized Trial Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression

TypeinterventionalSponsorThe Royal Ottawa Mental Health CentreRan2024 to 2027Enrolled210ConditionsDepression, Depressive Disorder, Major, Depressive EpisodeArmsrepetitive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 9 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  8. Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Donel M MartinSchool of Psychiatry, University of New South Wales, Sydney, Australia. donel.martin@unsw.edu.au.
Shawn M McClintockNeurocognitive Research Laboratory, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jane ForsterSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Colleen K LooBlack Dog Institute, Sydney, Australia.
UNSW Sydney · AUBlack Dog Institute · AUThe University of Texas Southwestern Medical Center · US

Funding

Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)K23MH087739 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI MCCLINTOCK, SHAWN M · 2010 to 2014
$641k
NIMH NIH HHS K23 MH087739
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic intervention for neuropsychiatric illnesses and has demonstrated efficacy for treatment of major depression. However, an unresolved question is whether a course of rTMS treatment results in effects on cognitive functioning. In this systematic review and meta-analysis we aimed to quantitatively determine whether a course of rTMS has cognitive enhancing effects. We examined cognitive outcomes from randomised, sham-controlled studies conducted in patients with neuropsychiatric conditions where rTMS was administered to the dorsolateral prefrontal cortex (DLPFC) across repeated sessions, searched from PubMed/MEDLINE and other databases up until October 2015. Thirty studies met our inclusion criteria. Cognitive outcomes were pooled and examined across the following domains: Global cognitive function, executive function, attention, working memory, processing speed, visual memory, verbal memory and visuospatial ability. Active rTMS treatment was unassociated with generalised gains across the majority of domains of cognitive functioning examined. Secondary analyses revealed a moderate sized positive effect for improved working memory in a small number of studies in patients with schizophrenia (k = 3, g = 0.507, 95 % CI = [0.183-0.831], p < .01). Therapeutic rTMS when administered to the DLPFC in patients with neuropsychiatric conditions does not result in robust cognitive enhancing effects.

Indexed as

CognitionTranscranial Magnetic StimulationHumansMental DisordersRandomized Controlled Trials as TopicCognitionDepressionNeuropsychiatricRepetitive transcranial magnetic stimulationSchizophreniaWorking memory

Identifiers

PMID27632386
PMCPMC5949868
OpenAlexW2510023404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.