ArticlePLoS neglected tropical diseases2016
The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Helminths as architects of trained tolerance: implications for human health.Clinical & translational immunology · 2026Review
- The Impact of Helminths on Colorectal Cancer: From Infections to the Isolation of Biotherapeutics.Pathogens (Basel, Switzerland) · 2025Review
- Early-life infectious disease exposure, the "hygiene hypothesis," and lifespan: Evidence from hookworm disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Soil-Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species-Specific Effects Within the Old Friends Hypothesis.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- A Honduran Prevalence Study on Soil-Transmitted Helminths Highlights Serological Antibodies to Tm-WAP49 as a Diagnostic Marker for Exposure to Human Trichuriasis.The American journal of tropical medicine and hygiene · 2025Article
- Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair.Results and problems in cell differentiation · 2024Review
- The Underrated Gut Microbiota Helminths, Bacteriophages, Fungi, and Archaea.Life (Basel, Switzerland) · 2023Review
- Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.Parasite immunology · 2023Article
- Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas.Parasite immunology · 2022Article
- Detangling the Crosstalk BetweenFrontiers in cellular and infection microbiology · 2022Review
- Recombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model.Microbiology spectrum · 2021Article
- Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis.Parasites & vectors · 2021Article
- Article
- Mining Anti-Inflammation Molecules FromFrontiers in cellular and infection microbiology · 2021Article
- Reinterpreting patterns of variation in human thyroid function: An evolutionary ecology perspective.Evolution, medicine, and public health · 2021Review
- Whipworm Infection Promotes Bacterial Invasion, Intestinal Microbiota Imbalance, and Cellular Immunomodulation.Infection and immunity · 2020Article
- Inflammaging in Endemic Areas for Infectious Diseases.Frontiers in immunology · 2020Review
- Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis.Frontiers in immunology · 2020Review
- Clinical Use ofFrontiers in immunology · 2020Review
- Host Immunity and Inflammation to Pulmonary Helminth Infections.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Current iterations of the hygiene hypothesis suggest an adaptive role for helminth parasites in shaping the proper maturation of the immune system. However, aspects of this hypothesis are based on assumptions that may not fully account for realities about human helminth infections. Such realities include evidence of causal associations between helminth infections and asthma or inflammatory bowel disease as well as the fact that helminth infections remain widespread in the United States, especially among populations at greatest risk for inflammatory and autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.