Evidence map›Paper›PMID 27631817›Full record

ReviewDer Nervenarzt2016

[Pharmacological treatment of women with epilepsy before and during pregnancy].

B Müffelmann, C G Bien

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution.

B MüffelmannEpilepsie-Zentrum Bethel, Krankenhaus Mara I, Maraweg 17-21, 33617, Bielefeld, Deutschland. Birgitt.Mueffelmann@mara.de.
C G BienEpilepsie-Zentrum Bethel, Krankenhaus Mara I, Maraweg 17-21, 33617, Bielefeld, Deutschland.
Krankenhaus Mara

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the vast majority of women with epilepsy, no complications occur during pregnancy. Important for that is early, preconceptional counseling and close surveillance during pregnancy. The aim should be to maintain the best possible seizure control without occurrence of generalized tonic-clonic seizures while using antiepileptic drugs and with the lowest possible risk of malformations. The warnings for the prescription of valproic acid in women of reproductive age were tightened because of the dose-dependent increase in the malformation rate and other risks, especially regarding adverse effects on childhood cognitive development. The pharmacokinetics of antiepileptic drugs in pregnancy require monitoring of serum drug levels and an early dose adjustment. Breastfeeding should be encouraged in women with epilepsy taking antiepileptic drugs as long as infants are closely monitored with respect to possible sedation and poor drinking.

Indexed as

Abnormalities, Drug-InducedAnticonvulsantsCongenital AbnormalitiesDose-Response Relationship, DrugDrug MonitoringEpilepsyEvidence-Based MedicineFemaleHumansPregnancyPregnancy ComplicationsRisk AssessmentTreatment OutcomeAnticonvulsantsAntiepileptic drugsCognitionEpilepsyMalformationPregnancy

Identifiers

PMID27631817
OpenAlexW2546909768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.