Evidence map›Paper›PMID 27631726›Full record

ArticleJournal of cancer research and clinical oncology2017

Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer.

Neveen Abd El Moneim Hussein, Zenat A El Kholy, Medhat M Anwar, Mohamed A Ahmad, Shaymaa M Ahmad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  7. Ratiometric electrochemical aptasensor based on functionalized graphene nanocomposites for detection of CA19-9.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
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  19. Micro RNAs and Circular RNAs in Different Forms of Otitis Media.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Neveen Abd El Moneim HusseinApplied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. neveen39@yahoo.com.
Zenat A El KholyApplied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Medhat M AnwarExperimental and Clinical Surgery Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Mohamed A AhmadClinical Pathology Department, Medical Military Academy, Alexandria, Egypt.
Shaymaa M AhmadApplied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Alexandria University · EGMilitary Medical Academy · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnosis of pancreatic cancer (PC) by using sensitive and specific biomarkers is considered necessary. MiRNAs are master regulators of gene expression and several biological processes, and they are dysregulated in various cancers, where they play a vital role in either cancer progression or suppression. So, this study was designed to investigate the role of plasma miR-22-3p, miR-642b-3p and miR-885-5p expression as possible diagnostic markers in PC patients as compared to serum CA19-9. In addition, the correlation of those miRNAs and CA19-9 with clinical characteristics of PC patients was analyzed.

methodsThe expression levels of selected miRNAs and serum CA19-9 concentration were determined for 35 patients with PDAC and 15 healthy controls by quantitative real-time RT-PCR and electro-chemiluminescence immune assay, respectively. The sensitivities of miRNAs as biomarkers of PC were evaluated and compared with CA19-9 using a receiver operating characteristic analysis.

resultsThe levels of three miRNAs (miR-22-3p, miR-642b-3p and miR-885-5p) and CA19-9 were significantly higher in PC patients, even those with early-stage disease (IB and IIB), than in healthy control. Both miRNAs and CA19-9 were associated with tumor stage. The high sensitivities of the three selected miRNAs and CA19-9 were observed.

conclusionThe measurement of miR-22-3p, miR-642b-3p and miR-885-5p may prove to have clinical utility in diagnosis of PC. Those miRNAs are ideal early biomarkers for PC diagnosis. So, they can effectively be used with serum CA19-9 for PC screening in early tumor stage.

Indexed as

AdultAgedBiomarkers, TumorCase-Control StudiesFemaleHumansMaleMicroRNAsMiddle AgedNeoplasm StagingPancreatic NeoplasmsROC CurveBiomarkers, TumorMicroRNAsMIRN22 microRNA, humanMIRN642 microRNA, humanMIRN885 microRNA, humanCA19-9 and real-time RTPCRmiR-22-3pmiR-642b-3pmiR-885-5pPancreatic cancer

Identifiers

PMID27631726
PMCPMC11819002
OpenAlexW2519927854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.