ArticleEndocrinology2016
Foxo1 Is Required for Normal Somatotrope Differentiation.
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Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.Cell reports · 2026Article
- NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary.Endocrinology · 2026Article
- ScRNAseq Analysis of Chicken Embryonic Pituitary Reveals Cell Heterogeneity and a Cell Type Coexpressing Gh and Pomc.Endocrinology · 2025Article
- The interplay between FOXO1 and glucocorticoid signaling in promoting the terminal differentiation of somatotropes.Molecular and cellular endocrinology · 2025Article
- Update on regulation of GHRH and its actions on GH secretion in health and disease.Reviews in endocrine & metabolic disorders · 2025Review
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes.Frontiers in endocrinology · 2025Article
- FOXO1 regulates expression of Neurod4 in the pituitary gland.Molecular and cellular endocrinology · 2024Article
- Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells.Cancers · 2022Review
- Difference in miRNA Expression in Functioning and Silent Corticotroph Pituitary Adenomas Indicates the Role of miRNA in the Regulation of Corticosteroid Receptors.International journal of molecular sciences · 2022Article
- FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth.Endocrinology · 2022Article
- Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development.Nature communications · 2020Article
- Complex integration of intrinsic and peripheral signaling is required for pituitary gland development.Biology of reproduction · 2018Review
- Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia.Endocrinology · 2018Article
- Natural and molecular history of prolactinoma: insights from aOncotarget · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Jyoti KapaliDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Brock E KabatDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Kelly L SchmidtDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Caitlin E StallingsDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Mason TippyDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Deborah O JungDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Brian S EdwardsDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Leah B NantieDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Lori T RaeztmanDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Amy M NavratilDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Buffy S EllsworthDepartment of Physiology (J.K., B.E.K., K.L.S., C.E.S., M.T., D.O.J., B.S.El.), Southern Illinois University, Carbondale, Illinois 62901-6523; Department of Zoology and Physiology (B.S.Ed., A.M.N.), University of Wyoming, Laramie, Wyoming 82071; and Department of Molecular and Integrative Physiology (L.B.N., L.T.R.), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Southern Illinois University Carbondale · USUniversity of Illinois Urbana-Champaign · USUniversity of Wyoming · US
Funding
Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Robert Scott Seville · 2012 to 2026
$56.8MWyoming IDeA Networks of Biomedical Research ExcellenceP20RR016474 · NCRR · UNIVERSITY OF WYOMING · PI LIBERLES, DAVID A. · 2001 to 2011
$28.2MWisconsin Allergy Research Training (WISCART) ProgramT32AI007635 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2000 to 2026
$6.5MNotch Signaling Regulates Pituitary OrganogenesisR01DK076647 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RAETZMAN, LORI T · 2007 to 2016
$2.7MMechanism by Which FOXO1 Regulates Somatotrope Differentiation and/or FunctionR15HD078885 · NICHD · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI ELLSWORTH, BUFFY SUE · 2014 to 2014
$443kThe Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland DevelopR15HD063469 · NICHD · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI ELLSWORTH, BUFFY SUE · 2010 to 2010
$218kNCRR NIH HHS P20 RR016474NIAID NIH HHS T32 AI007635NICHD NIH HHS R15 HD063469NICHD NIH HHS R15 HD078885NIDDK NIH HHS R01 DK076647NIGMS NIH HHS P20 GM103432
Abstract
The etiology for half of congenital hypopituitarism cases is unknown. Our long-term goal is to expand the molecular diagnoses for congenital hypopituitarism by identifying genes that contribute to this condition. We have previously shown that the forkhead box transcription factor, FOXO1, is present in approximately half of somatotropes at embryonic day (e) 18.5, suggesting it may have a role in somatotrope differentiation or function. To elucidate the role of FOXO1 in somatotrope differentiation and function, Foxo1 was conditionally deleted from the anterior pituitary (Foxo1
Indexed as
AnimalsCell DifferentiationEmbryo, MammalianExonsFemaleFollicle Stimulating HormoneForkhead Box Protein O1ImmunohistochemistryIn Situ HybridizationLuteinizing HormoneMicePituitary GlandPregnancySomatotrophsStem CellsTime FactorsFollicle Stimulating HormoneForkhead Box Protein O1Foxo1 protein, mouseLuteinizing Hormone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.