ArticlePlant molecular biology2016
Trichome patterning control involves TTG1 interaction with SPL transcription factors.
Article in Plant molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 46 citations in OpenAlex.
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- miR156 Is a Negative Regulator of Aluminum Response inPlants (Basel, Switzerland) · 2025Article
- Comparative transcriptome analysis reveals genes involved in trichome development and metabolism in tobacco.BMC plant biology · 2024Article
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- Potassium transporter TRH1/KUP4 contributes to distinct auxin-mediated root system architecture responses.Plant physiology · 2022Article
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- Gene expression underlying floral epidermal specialization in Aristolochia fimbriata (Aristolochiaceae).Annals of botany · 2021Article
- Analysis and review of trichomes in plants.BMC plant biology · 2021Review
- Characterization of Squamosa-Promoter Binding Protein-Box Family Genes Reveals the Critical Role ofFrontiers in plant science · 2021Article
- Comparative Metabolite and Gene Expression Analyses in Combination With Gene Characterization Revealed the Patterns of Flavonoid Accumulation DuringFrontiers in plant science · 2021Article
- Characterization of the regulation mechanism of grapevine microRNA172 family members during flower development.BMC plant biology · 2020Article
- TRANSPARENT TESTA GLABRA1, a Key Regulator in Plants with Multiple Roles and Multiple Function Mechanisms.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermal cell differentiation is a paramount and conserved process among plants. In Arabidopsis, a ternary complex formed by MYB, bHLH transcription factors and TTG1 modulates unicellular trichome morphogenesis. The formation of multicellular glandular trichomes of the xerophytic shrub Cistus creticus that accumulate labdane-type diterpenes, has attained much attention renowned for its medicinal properties. Here, we show that C. creticus TTG1 (CcTTG1) interacts with the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPLA/B) proteins, putative homologs of AtSPL4/5 that in turn interact with AtTTG1. These interactions occur between proteins from evolutionarily distant species supporting the conserved function of TTG1-SPL complex. Overexpression of AtSPL4 and AtSPL5 decreased the expression of GLABRA2 (AtGL2), the major regulator of trichome morphogenesis, resulting in trichome reduction on the adaxial surface of cauline leaves, thereby illuminating the significance of TTG1-SPLs interactions in trichome formation control. AtGL2 and AtSPL4 have opposite expression patterns during early stages of leaf development. We postulate an antagonistic effect between SPLs and the heterogeneous MYB-bHLH factors binding to TTG1. Hence, the SPLs potentially rearrange the complex, attenuating its transcriptional activity to control trichome distribution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.