Evidence map›Paper›PMID 27631407›Full record

ArticleMedicine, health care, and philosophy2017

Foetal surgery and using in utero therapies to reduce the degree of disability after birth. Could it be morally defensible or even morally required?

Constantinos Kanaris

Abstract read
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In one paragraph

Article in Medicine, health care, and philosophy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Constantinos KanarisPaediatric Intensive Care Unit, Royal Manchester Children's Hospital, Manchester, UK. ckanaris@doctors.net.uk.ORCID http://orcid.org/0000-0002-4017-4553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2008 the Human Fertilisation and Embryology Act amendments made deliberately choosing to bring disability into the world, using assisted reproduction, a criminal offence. This paper considers whether the legal prohibition above, should influence other policy areas concerning the welfare of future children such as new possibilities presented by foetal surgery and in utero gene therapy. If we have legal duties to avoid disability in one context should this influence our avoidance of disability in this other context? This paper investigates whether the State might have a stake in wider promotion of practices to reduce the degree of disability in foetuses that will come to exist (as opposed to those that will be aborted). Not selecting for disability does not affect the welfare of any future individual, whereas treating in utero abnormalities can optimize the eventual child's welfare; antenatal interventions stand to improve clinical outcomes and welfare should that specific child be born. I explore why the State may want to intervene in the antenatal setting and to what extent, if at all; the State should implement these technologies. I argue that if the State is justified in intervening to outlaw the choosing to create disabled lives using assisted reproductive techniques, it is also justified in putting pressure on prospective parents to accept therapies in utero to help their child be born less disabled. However, I qualify this with the argument that the State is not justified in using force or the criminal law in this situation during pregnancy.

Indexed as

ChildChild WelfareFemaleFetal DiseasesFetusHuman RightsHumansInfant, NewbornInfant, Newborn, DiseasesPersons with DisabilitiesPregnancyPrenatal DiagnosisRisk AssessmentUnited KingdomUnited StatesAdvanced reproductive technologiesDisabilityDisability rightsFoetal rightsFoetal surgeryFoetal therapyGeneticsGenetic screeningHuman enhancementIn utero gene therapyParentalPregnancyPublic healthcare policyResponsibility

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.