Evidence map›Paper›PMID 27631365›Full record

ArticleAIDS and behavior2017

Patterns of HIV Treatment Adherence do not Differ Between Male and Female Adolescents in Botswana.

Kimon L H Ioannides, Jennifer Chapman, Tafireyi Marukutira, Ontibile Tshume, Gabriel Anabwani, Robert Gross, Elizabeth D Lowenthal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kimon L H IoannidesDepartments of Pediatrics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Room 1513, Philadelphia, PA, USA.
Jennifer ChapmanChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Tafireyi MarukutiraBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Ontibile TshumeBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Gabriel AnabwaniBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Robert GrossDepartments of Medicine (Infectious Diseases) and Epidemiology, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Room 1513, Philadelphia, PA, USA.
Elizabeth D LowenthalDepartments of Pediatrics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Room 1513, Philadelphia, PA, USA. lowenthale@email.chop.edu.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube · 2013 to 2026
$23.5M
Targeted Monitoring and Determinants of Adherence in Adolescents with HIVK23MH095669 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN · 2012 to 2016
$874k
NIAID NIH HHS L40 AI090971NIAID NIH HHS P30 AI045008NIMH NIH HHS K23 MH095669NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

We hypothesized that longer and more frequent dosing gaps among boys in Botswana taking antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection compared to girls could account for previously seen gender-specific differences in outcomes. We monitored 154 male and 134 female adolescents for 2 years with medication event monitoring systems (MEMS). Median adherence was 95.6 % for males and 95.7 % for females (p = 0.40). There were no significant gender differences in the number of ≥7 day (p = 0.55) and ≥14 day (p = 0.48) dosing gaps. The median maximal gap was 7.7 days for males and 8.0 days for females (p = 0.47). These findings are not consistent with clinically meaningful gender differences in adherence.

Indexed as

Medication AdherenceAdolescentAnti-HIV AgentsBotswanaFemaleHIV InfectionsHumansMaleProspective StudiesSex FactorsAnti-HIV AgentsAfricaAntiretroviral therapyARTMEMS

Identifiers

PMID27631365
PMCPMC5776686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.